Elements of Numerical Mathematical Economics with Excel: Static and Dynamic Optimization shows readers how to apply static and dynamic optimization theory in an easy and practical manner, without requiring the mastery of specific programming languages that are often difficult and expensive to learn. Featuring user-friendly numerical discrete calculations developed within the Excel worksheets, the book includes key examples and economic applications solved step-by-step and then replicated in Excel. After introducing the fundamental tools of mathematical economics, the book explores the classical static optimization theory of linear and nonlinear programming, applying the core concepts of microeconomics and some portfolio theory. This provides a background for the more challenging worksheet applications of the dynamic optimization theory. The book also covers special complementary topics such as inventory modelling, data analysis for business and economics, and the essential elements of Monte Carlo analysis. Practical and accessible, Elements of Numerical Mathematical Economics with Excel: Static and Dynamic Optimization increases the computing power of economists worldwide. This book is accompanied by a companion website that includes Excel examples presented in the book, exercises, and other supplementary materials that will further assist in understanding this useful framework.

Seven months after the report of the cloning of the CF gene by three North American groups, a workshop scheduled before that report was held in sestri Levante, a splendid city on the Ligu- rian coast. For three days almost 100 scientists from Europe and North America had the opportunity to discuss the perspectives and the new research strategies opened up by the cloning of the gene. The issue of publishing these proceedings was discussed at length among the invited speakers of the workshop and the pre- vailing opinion was that they would be worthwhile if accompanied by the transcripts of the discussions which followed each pre- sentation. Thanks to the generous suppport of the Menarini Foun- dation, represented at the meeting by Dr. Sergio Gorini, and thanks to the reviewing work done by the Chairpersons of each session, by many participants, by Dr. Donata Brugioni, by Mrs. Katherine Loparco and by my collaborators Drs. Marcella Devoto and Luis J. V. Galietta, that idea has generated this book, which should be a helpful tool at least for some years for all those interested in understanding how the CFTR gene works. Prof. G. Romeo CONTENTS Cystic Fibrosis - A Strategy for the Future *...*. 1 R. Williamson Molecular Genetics of cystic Fibrosis ...*...*. . 9 L. -C. Tsui, J. Rommens, B. Kerem, R. Rozmahel, J. Zielenski, D. Kennedy, D. Markiewicz, N. Plavsic, J. -L. Chou, D. Bozon and M.