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This atlas explores the latest advances in radionuclide imaging in
the field of inflammatory diseases and infections, which now
typically includes multimodality fusion imaging (e.g. in SPECT/CT
and in PET/CT). In addition to describing the pathophysiologic and
molecular mechanisms on which the radionuclide imaging of
infection/inflammation is based, the clinical relevance and impact
of such procedures are demonstrated in a collection of richly
illustrated teaching cases, which describe the most commonly
observed scintigraphic patterns, as well as anatomic variants and
technical pitfalls. Special emphasis is placed on using tomographic
multimodality imaging to increase both the sensitivity and
specificity of radionuclide imaging. The aim of the second edition
of this book is to update the first (published in 2013) by
reflecting the changes in this rapidly evolving field. Particular
attention is paid to the latest advances in the radionuclide
imaging of infection and inflammation, including the expanding role
of hybrid imaging with [18F]FDG PET/CT SPECT/CT, without neglecting
new radiotracers proposed for the imaging of
infection/inflammation. Written by respected experts in the field,
the book will be an invaluable tool for residents in nuclear
medicine, as well as for other specialists.
The main goal of the second edition of this book is to update the
content on the rapidly growing field of lymphoscintigraphy, a
radionuclide-based imaging procedure that provides information on
the functional status of the lymphatic system. Although the
technique was originally introduced to identify the cause of
peripheral edema (i.e., blockage of the venous or lymphatic
circulation), more recent and widespread applications include
radioguided biopsy of the sentinel lymph node in patients with
solid cancers. This procedure is crucial for the adequate planning
of oncologic surgery in a growing number of cancers, most notably
breast cancer, cutaneous melanoma, head and neck cancers, penile
cancer, and cervical cancer. The book focuses on the latest
advances in lymphoscintigraphy techniques, including both novel
tracers recently approved for clinical use (especially in the field
of sentinel lymph node mapping) and the expanding role of hybrid
imaging with SPECT/CT - and in sentinel node detection using hybrid
tracers (radiolabeled and fluorescent) for dual-signature guidance.
Each chapter addresses the clinical application of
lymphoscintigraphy in different anatomic areas or disease
conditions. After an introductory section concerning the
pathophysiology of the specific site/disease, the clinical
relevance and impact of lymphoscintigraphy is demonstrated by a
collection of richly illustrated teaching cases describing the
lymphoscintigraphic patterns most commonly observed, as well as
anatomic variants and technical pitfalls. Emphasis is placed on
tomographic multimodality imaging. The book gathers contributions
by experts in nuclear oncology, who have revised their chapters by
updating the didactic material and adding clinical cases. Regarding
sentinel lymph node biopsy in particular, a major distinction of
this text is the incorporation of the staging guidelines of the
American Joint Committee on Cancer (8th edition) into the didactic
material.
This atlas fills a gap in the literature by documenting in detail
the role of nuclear medicine imaging of infection and inflammation.
The pathophysiologic and molecular mechanisms on which radionuclide
imaging of infection/inflammation is based are clearly explained,
but the prime focus of the book is on the clinical relevance of
such procedures. Their impact is demonstrated by a collection of
richly illustrated teaching cases that describe the most commonly
observed scintigraphic patterns, as well as anatomic variants and
technical pitfalls. Due attention is paid to the application of
recently developed techniques, including multimodality fusion
imaging such as SPECT/CT and PET/CT. Emphasis is placed in
particular on the ability of multimodality imaging to increase both
the sensitivity and the specificity of radionuclide imaging. This
atlas will be an excellent learning tool for residents in nuclear
medicine and illuminating for other specialists with an interest in
the field.
Although lymphoscintigraphy was originally introduced into clinical
routine for identification of the cause of peripheral edema, more
recently it has been widely applied for radioguided biopsy of the
sentinel lymph node in patients with solid cancers. The procedure
is now considered crucial for adequate planning of oncologic
surgery in a growing number of cancers. This atlas presents a
collection of richly illustrated teaching cases that demonstrate
the clinical relevance and impact of lymphoscintigraphy in
different pathologic conditions. After introductory chapters on the
anatomy, physiology, and pathophysiology of lymphatic circulation,
the role of lymphoscintigraphy in differential diagnosis of
peripheral edema and characterization of intracavitary lymph
effusions is addressed. The principal focus of the book, however,
is on the use of lymphoscintigraphic mapping for radioguided
sentinel node biopsy in cutaneous melanoma and cancers at a range
of anatomic sites. The most commonly observed lymphoscintigraphic
patterns are depicted, and anatomic variants and technical pitfalls
of the procedure receive careful attention. The role of tomographic
multimodality imaging is also considered. The atlas will be an
excellent learning tool for residents in nuclear medicine and other
specialists with an interest in the field.
Hemostatis and Desmopressin: Molecular Mechanisms of Cellular
Responses to DDAVP; S. Hashemi, et al. Pharmacology and
Pharmacodynamics of Desmopressin: Toxicity of Desmopressin and
Related Peptides; L.B. Kinter, et al. Desmopressin in Renal
Disease: Control of Bleeding in Uremic Patients; Y. Sultan.
Desmopressin and Platelets: Desmopressin in the Treatment of
Congenital and Acquired Defects of Platelet Function; M. Cattaneo,
P.M. Mannucci. Desmopressin and Surgery: Desmopressin, von
Willenbrand Factor, and Surgery; M. Weinstein. Desmopressin and
Blood Donation: Effects of Desmopressin on Normal Donors in Plasma
Exchange Donations; R.J. Sassetti, B.C. McLeod. Clinical
Applications of Desmopressin in Hemophilia and von Willenbrand's
Disease: Intravenous and Subcutaneous Desmopressin; M. Kohler, G.
Mariani. SideEffects and Adverse Reactions of Desmopressin: DDAVP
and Tachyphylaxis in Healthy Subjects; V. Vicente, et al.
Recapitulation: General Recapitulation and Search for a Consensus;
P.M. Mannucci, et al. 33 additional articles. Index.
This multidisciplinary textbook is designed to be the standard on
the subject and is geared for use by physicians who are involved in
the care and/or diagnosis of cancer patients, including general
surgeons, nuclear medicine physicians, oncologists, and
pathologists. Contributors to this book represent key members of
the care team and include some of the most prestigious names in the
field. Comprehensive coverage is provided on all aspects of
radioguided surgery, including radiation protection, training,
sentinel lymph node biopsy, and non-sentinel lymph node
applications for various cancers, tumors, and lesions. Practical
information is readily accessible and throughout there is an
emphasis on improved decision making. For instance, discussions of
lymph node staging, anatomy, and physiology provide rationale for
performing radioguided studies and techniques. Sentinel node
localization and radioimmunoguided therapy are compared and
contrasted in order to define the appropriate use of each modality.
Tables present the indications, performance, and interpretation of
procedures at a glance. Key data on radiopharmaceuticals and
sentinel node localization devices are centrally compiled so that
readers can easily identify the characteristics of equipment and
agents. A wealth of illustrations completes this authoritative
reference and enhances the effective application of new concepts.
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