Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.

Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ]+++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Gesta Friderici I. Et Heinrici VI. Imperatorum; Volume 30 Of 7]; Monumenta Germaniae Historica / 1 Godefridus (Viterbiensis), Georg Heinrich Pertz Hahn, 1870

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Ubmrei Reinerus (Alemannus), Friedrich Jacob, Godefridus (...) Rohden, 1838

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.

The Making of Modern Law: Foreign, Comparative and International Law, 1600-1926, brings together foreign, comparative, and international titles in a single resource. Its International Law component features works of some of the great legal theorists, including Gentili, Grotius, Selden, Zouche, Pufendorf, Bijnkershoek, Wolff, Vattel, Martens, Mackintosh, Wheaton, among others. The materials in this archive are drawn from three world-class American law libraries: the Yale Law Library, the George Washington University Law Library, and the Columbia Law Library.Now for the first time, these high-quality digital scans of original works are available via print-on-demand, making them readily accessible to libraries, students, independent scholars, and readers of all ages.+++++++++++++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: +++++++++++++++Yale Law LibraryLP3Y100150019010101The Making of Modern Law: Foreign, Comparative, and International Law, 1600-1926Translated from the original Latin by Charles Ambrose Lorenz.Capetown; Port Elizabeth; Grahamstown; Johannesburg; Stellenbosch; King Williamstown: J. C. Juta & Co., 1901xxi, 374 p., 19 cmSouth Africa

This is a reproduction of a book published before 1923. This book may have occasional imperfectionssuch as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed worksworldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Auctarium Exhortationum Ad Religiosos: De Praecipuis Anni Temporibus, & Festiuitatibus Vt Christi Domini Nostri, Beatissimae Virginis Mariae & Aliorum Nonnullorum Sanctorum ... Johann Dirckinck ((S.I.)), Godefridus Meucher (Viuda de) sumptibus Godefridi Meucheri bibliopolae, 1718

This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone!

This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone

Oorspronkelijke Verhalen En Gelijktijdige Berichten Van Den Moord Gepleegd Op Prins Willem Van Oranje. This Book Is In Dutch.

A book of many puzzles mostly in the Sudoku family, many of which are Killer Sudoku. There are many hints as to how these puzzles are made. Also included Kakuro, Futoshiki, Hittori, Slitherlink and others. Try your hand at the original puzzles, as invented in the eighteenth century by the great Swiss mathematician, Leonhard Euler.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Specimina Charitatis Et Doctrinae Quae Continenturin Quatuor Libellis Contra Presbyteros Regulares In Belgio Sparsis Godefridus Veramantius Joannem Langenberg, 1738

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Acta Sanctorum: Quotquot Toto Orbe Coluntur, Vel A Catholicis Scriptoribus Celebrantur. Augustus; T. 3, Quo Dies Decimus Tertius, Decimus Quartus, Decimus Quintus, Decimus Sextus, Decimus Septimus, Decimus Octavus, & Decimus Nonus Continentur, Volume 8; Acta Sanctorum: Quotquot Toto Orbe Coluntur, Vel A Catholicis Scriptoribus Celebrantur. Augustus; T. 3, Quo Dies Decimus Tertius, Decimus Quartus, Decimus Quintus, Decimus Sextus, Decimus Septimus, Decimus Octavus, & Decimus Nonus Continentur; Daniel Papebrochius Johannes Bolland, Godefridus Henschenius, Daniel Papebrochius, Joseph van Hecke, Joseph Vandermoere, Cornelius Bye Meursius, 1737

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Acta Sanctorum: Quotquot Toto Orbe Coluntur, Vel a Catholicis Scriptoribus Celebrantur. Augustus; T. 3, Quo Dies Decimus Tertius, Decimus Quartus, Decimus Quintus, Decimus Sextus, Decimus Septimus, Decimus Octavus, & Decimus Nonus Continentur, Volume 8; Acta Sanctorum: Quotquot Toto Orbe Coluntur, Vel A Catholicis Scriptoribus Celebrantur. Augustus; T. 3, Quo Dies Decimus Tertius, Decimus Quartus, Decimus Quintus, Decimus Sextus, Decimus Septimus, Decimus Octavus, & Decimus Nonus Continentur; Daniel Papebrochius Johannes Bolland, Godefridus Henschenius, Daniel Papebrochius, Joseph van Hecke, Joseph Vandermoere, Cornelius Bye Meursius, 1737