Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

The rapid advancement in encryption and network computing gave birth to new tools and products that have influenced the local and global economy alike. One recent and notable example is the emergence of virtual currencies, also known as cryptocurrencies or digital currencies. Virtual currencies, such as Bitcoin, introduced a fundamental transformation that affected the way goods, services, and assets are exchanged. Virtual currencies are experiencing an increasing popularity in the financial markets and in portfolio management as can be classified as financial asset or commodities on a scale from pure medium of exchange advantages to pure store of value advantages. As a result of its distributed ledgers based on blockchain, cryptocurrencies offer some unique advantages to the economy, investors, and consumers, but also pose considerable risks to users and challenges for regulators when fitting the new technology into the old legal framework. Bitcoin for example may be useful in risk management and ideal for risk-averse investors in anticipation of negative shocks to the market. The core objective of this proposed book is to provide a comprehensive discussion on the important issues related to cryptocurrencies ranging from pricing, financial, legal to technological aspects.

New York Times bestseller Journey into the universe through the most spectacular sights in astronomy in stereoscopic 3D Welcome to the Universe in 3D takes you on a grand tour of the observable universe, guiding you through the most spectacular sights in the cosmos-in breathtaking 3D. Presenting a rich array of stereoscopic color images, which can be viewed in 3D using a special stereo viewer that folds easily out of the cover of the book, this book reveals your cosmic environment as you have never seen it before. Astronomy is the story of how humankind's perception of the two-dimensional dome of the sky evolved into a far deeper comprehension of an expanding three-dimensional cosmos. This book invites you to take part in this story by exploring the universe in depth, as revealed by cutting-edge astronomical research and observations. You will journey from the Moon through the solar system, out to exoplanets, distant nebulas, and galaxy clusters, until you finally reach the cosmic microwave background radiation (or CMB), the most distant light we can observe. The distances to these celestial wonders range from 1.3 light-seconds to 13.8 billion light-years. Along the way, the authors explain the fascinating features of what you are seeing, including how the 3D images were made using the same technique that early astronomers devised to measure distances to objects in space. The dramatic 3D images in this one-of-a-kind book will astonish you, extending your vision out to the farthest reaches of the universe. You will never look up into the night sky the same way again.

This book is aimed squarely at the Independent Software Vendor (ISV) who is considering Force.com as a route to market their software offerings. Alternatively you could be part of a corporate IT department looking to deliver solutions more quickly for your business users. You have many of the same issues as the ISV, but from a slightly different perspective. This book is intended to be a catalyst for action aimed at a range of people inside and outside your organization

The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. Nucleoside and nonnucleoside RT inhibitors remain important components in frequently used drug regimens to treat the infection. RT inhibitors also play important roles in recently validated strategies to prevent transmission of the virus. The relevance of HIV-1 RT as a drug target has simultaneously triggered interest in basic research studies aimed at providing a more detailed understanding of interactions between proteins, nucleic acids, and small molecule ligands in general terms. In light of the ever-growing knowledge on structure and function of HIV-1 RT, this enzyme serves as a valuable "model system" in efforts to develop novel experimental tools and to explain biochemical processes. This monograph is designed to provide an overview of important aspects in past and current HIV-1 RT research, with focus on mechanistic aspects and translation of knowledge into drug discovery and development. The first section includes chapters with emphasis placed on the coordination of the RT-associated DNA polymerase and ribonuclease H (RNase H) activities. The second covers mechanisms of action and future perspectives associated with NRTIs and NNRTIs, while the third section includes chapters focusing on novel strategies to target the RT enzyme. Chapters of the final part are intended to discuss mechanisms involved in HIV variability and the development of drug resistance. We hope that these contributions will stimulate interest, and encourage research aimed at the development of novel RT inhibitors. The lack of bona fide RNase H inhibitors with potent antiviral activity provides an example for challenges and opportunities in the field.

A pocket-style edition based on the New York Times bestseller A Brief Welcome to the Universe offers a breathtaking tour of the cosmos, from planets, stars, and galaxies to black holes and time loops. Bestselling authors and acclaimed astrophysicists Neil deGrasse Tyson, Michael A. Strauss, and J. Richard Gott take readers on an unforgettable journey of exploration to reveal how our universe actually works. Propelling you from our home solar system to the outermost frontiers of space, this book builds your cosmic insight and perspective through a marvelously entertaining narrative. How do stars live and die? What are the prospects of intelligent life elsewhere in the universe? How did the universe begin? Why is it expanding and accelerating? Is our universe alone or part of an infinite multiverse? Exploring these and many other questions, this pocket-friendly book is your passport into the wonders of our evolving cosmos.

The book offers a comprehensive perspective on the highly topical issue of protecting and promoting labour standards in international economic law and the globalized economy. For the purpose of an in-depth analysis of both the specific and the fundamental aspects in this regard, it combines views from specialized academics of the legal and political sciences as well as experienced practitioners. The contributions to this book do not only reveal recurring obstacles but also point at best practices and potential for synergies, providing important guidance for future research and practice in international economic and labour law and policy.

RNA processing plays a critical role in realizing the full potential of a given genome. One means of achieving protein diversity is through RNA editing. A diverse array of editing events has been characterized, affecting gene expression in organisms from viruses and single cell parasites to humans and plants. The variety of editing mechanisms has required the development of many different experimental approaches, many of which are likely to be broadly applicable, particularly given the interplay between editing and other cellular processes, including transcription, splicing, and RNA silencing. This volume not only covers most of the principal methods employed in the field, but also offers innovative solutions to the significant challenges posed by these experimental systems.
* Presents newly developed methods
* Covers topics ranging from biochemistry to bioinformatics
* Includes innovative solutions to potential problems