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Natural products play crucial roles in modern drug development, and
constitute a prolific source of novel lead compounds or
pharmacophores for ongoing drug discovery programs. Chemistry and
Pharmacology of Naturally Occurring Bioactive Compounds presents
cutting-edge research in the chemistry of bioactive natural
products and demonstrates how natural product research continues to
make significant contributions in the discovery and development of
new medicinal entities. In 21 chapters, this book highlights
chemistry and pharmaceutical potential of natural products in
modern drug discovery processes, and covers the synthesis and
semi-synthesis of potentially bioactive natural products. Written
for phytochemists, synthetic chemists, combinatorial chemists, as
well as other practitioners and students in related fields, the
book features chemical advances in naturally occurring organic
compounds and describes their chemical transformations and
structure-activity relationships.
Natural products play crucial roles in modern drug development, and
constitute a prolific source of novel lead compounds or
pharmacophores for ongoing drug discovery programs. Chemistry and
Pharmacology of Naturally Occurring Bioactive Compounds presents
cutting-edge research in the chemistry of bioactive natural
products and demonstrates how natural product research continues to
make significant contributions in the discovery and development of
new medicinal entities. In 21 chapters, this book highlights
chemistry and pharmaceutical potential of natural products in
modern drug discovery processes, and covers the synthesis and
semi-synthesis of potentially bioactive natural products. Written
for phytochemists, synthetic chemists, combinatorial chemists, as
well as other practitioners and students in related fields, the
book features chemical advances in naturally occurring organic
compounds and describes their chemical transformations and
structure-activity relationships.
Biotechnology of Microbial Enzymes: Production, Biocatalysis, and
Industrial Applications, Second Edition provides a complete survey
of the latest innovations on microbial enzymes, highlighting
biotechnological advances in their production and purification
along with information on successful applications as biocatalysts
in several chemical and industrial processes under mild and green
conditions. The application of recombinant DNA technology within
industrial fermentation and the production of enzymes over the last
three decades have produced a host of useful chemical and
biochemical substances. The power of these technologies results in
novel transformations, better enzymes, a wide variety of
applications, and the unprecedented development of biocatalysts
through the ongoing integration of molecular biology methodology,
all of which is covered insightfully and in-depth within the book.
This fully revised, second edition is updated to address the latest
research developments and applications in the field, from microbial
enzymes recently applied in drug discovery to penicillin
biosynthetic enzymes and penicillin acylase, xylose reductase, and
microbial enzymes used in antitubercular drug design. Across the
chapters, the use of microbial enzymes in sustainable development
and production processes is fully considered, with recent successes
and ongoing challenges highlighted.
Discovery and Development of Neuroprotective Agents from Natural
Products draws together global research on medicinal agents from
natural sources as starting points for the design of
neuroprotective drugs. From the prediction of promising leads and
identification of active agents to the extraction of complex
molecules, the book explores a range of important topics to support
the development of safer, more economical therapeutics for these
increasingly prevalent diseases. Beginning with an overview of
current developments in the field, the book goes on to explore the
identification, extraction and phytochemistry of such
neuroprotective agents as antioxidants, biophenols and naturally
occurring anti-inflammatory steroid analogues. Specific natural
sources of bioactive agents are reviewed, and the development of
these agents into therapeutics for a number of specific
neurological disorders, including Alzheimer's disease, Parkinson's
disease and ischemic brain stroke, are discussed. Combining the
expertise of specialists from around the world, this in the Natural
Products Drug Discovery series aims to support and encourage
researchers in the investigation of natural sources as starting
points for the development of standardized, safe and effective
neuroprotective drugs.
Green Synthetic Approaches for Biologically Relevant Heterocycles
reviews this significant group of organic compounds within the
context of sustainable methods and processes. Each clearly
structured chapter features in-depth coverage of various green
protocols for the synthesis of a wide variety of bioactive
heterocycles classified on the basis of ring-size and/or presence
of heteratoms(s). Techniques covered include microwave heating,
ultrasound, ionic liquids, solid phase, solvent-free, heterogeneous
catalysis, and aqueous media, along with multi-component reaction
strategies. This book also integrates advances in green chemistry
research into industrial applications and process developments.
Green Synthetic Approaches for Biologically Relevant Heterocycles
is an essential resource on green chemistry technologies for
academic researchers, R&D professionals, and students working
in medicinal, organic, natural product, and agricultural chemistry.
Discovery and Development of Anti-Breast Cancer Agents from Natural
Products presents cutting-edge research advances in the field of
bioactive natural products and natural drug formulations. This
volume in the Natural Products Drug Discovery series focuses on
molecules of natural origin and their synthetic analogs that show
promising potential to act as anti-breast cancer and
chemotherapeutic agents. Combining foundational background
information on cancer mechanisms with details of medicinal
structures from natural products, this volume compiles the latest
developments from across interdisciplinary fields. Discovery and
Development of Anti-Breast Cancer Agents from Natural Products will
serve as a valuable resource for researchers working to discover
promising leads for the development of novel pharmaceuticals for
breast cancer, highlighting a number of key structures from natural
products and exploring possible future developments in the area.
Green Synthetic Approaches for Biologically Relevant Heterocycles,
Second Edition, Volume One: Advanced Synthetic Techniques reviews
this significant group of organic compounds within the context of
sustainable methods and processes, expanding on the first edition
with fully updated coverage and a whole range of new chapters.
Volume One explores advanced synthetic techniques, with each
chapter presenting in-depth coverage of various green protocols for
the synthesis of a wide variety of bioactive heterocycles that are
classified on the basis of ring-size and/or the presence of
heteroatoms. Techniques covered range from high pressure
cycloaddition reactions and microwave irradiation to sustainable
one-pot domino reactions. This updated edition is an essential
resource on sustainable approaches for academic researchers,
R&D professionals, and students working across medicinal,
organic, natural product and green chemistry.
Organophosphorus Chemistry presents a groundbreaking resource in
this branch of organic chemistry that demonstrates how
phosphorus-containing compounds can be manipulated in a variety of
organic reactions. The authors give an overview of the newest
trends and synthesis strategies, introduce bioactive and
environmentally friendly organophosphorus compounds and show their
importance in mainstream organic chemistry.
Biotechnology of Microbial Enzymes: Production, Biocatalysis and
Industrial Applications provides a complete survey of the latest
innovations on microbial enzymes, highlighting biotechnological
advances in their production and purification along with
information on successful applications as biocatalysts in several
chemical and industrial processes under mild and green conditions.
Applications of microbial enzymes in food, feed, and pharmaceutical
industries are given particular emphasis. The application of
recombinant DNA technology within industrial fermentation and the
production of enzymes over the last 20 years have produced a host
of useful chemical and biochemical substances. The power of these
technologies results in novel transformations, better enzymes, a
wide variety of applications, and the unprecedented development of
biocatalysts through the ongoing integration of molecular biology
methodology, all of which is covered insightfully and in-depth
within the book.
Discovery and Development of Antidiabetic Agents from Natural
Products brings together global research on the medicinal chemistry
of active agents from natural sources for the prevention and
treatment of diabetes and associated disorders. From the
identification of promising leads, to the extraction and synthesis
of bioactive molecules, this book explores a range of important
topics to support chemists in the discovery and development of
safer, more economical therapeutics that are desperately needed in
response to this emerging global epidemic. Beginning with an
overview of bioactive chemical compounds from plants with
anti-diabetic properties, the book goes on to outline the
identification and extraction of anti-diabetic agents and
antioxidants from natural sources. It then explores anti-diabetic
plants from specific regions before looking more closely at the
background, isolation, and synthesis of key therapeutic compounds
and their derivatives, including Mangiferin, Resveratrol, natural
saponins, and alpha-glucosidase enzyme inhibitors. The book
concludes with a consideration of current and potential future
applications. Combining the expertise of specialists from around
the world, this volume aims to support and encourage medicinal
chemists investigating natural sources as starting points for the
development of standardized, safe, and effective antidiabetic
therapeutics.
Discovery and Development of Anti-inflammatory Agents from Natural
Products, the latest volume in the Natural Product Drug Discovery
series, presents cutting-edge research advances in the field of
bioactive natural products and natural drug formulations, with this
volume focusing on molecules of natural origin and their synthetic
analogues that have the potential to act against the pathogens
responsible for inflammatory diseases. All aspects of each are
covered, including isolations and structure elucidations, in vitro
and in vivo biological activity, synthetic optimization,
investigations of pharmacodynamics and kinetics, and the
structure-activity relationships of anti-inflammatory natural
products. Written by active researchers and leading experts, this
book brings together an overview of current discoveries and trends
in this field. It will be a valuable resource for researchers
working to discover promising leads for the development of
pharmaceuticals in the prevention and treatment of
anti-inflammatory diseases.
Total Synthesis of Bioactive Natural Products provides step-by-step
guidelines for effectively synthesizing the most promising
bioactive agents from a broad range of natural products. Beginning
with a concise background that outlines the benefits and challenges
faced in effective synthesis, the book goes on to provide
individual outlines for approximately 100 of the most promising
bioactive agents. Taking a logical, user-friendly approach, the
systematic name, compound class, structure, natural source,
pharmaceutical potential and synthetic routes for each structure
are detailed, with clear illustrations throughout, making this book
an essential and practical guide for anyone working with both
synthesis and natural products.
Discovery and Development of Therapeutics from Natural Products
against Neglected Tropical Diseases draws together research on
medicinal agents from natural sources as starting points for the
design of drugs against Neglected Tropical Diseases (NTDs). From
the prediction of promising leads and identification of active
agents, to the extraction of complex molecules, the book explores
novel, economical and efficacious therapeutics for these diseases.
It describes current research and the role of natural products,
antimalarial compounds from marine natural products and
sesquiterpene lactones, natural antileprotic agents, natural
products with potential against Leishmaniasis, Trypanosomiasis and
Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids
for developing new antiprotozoal agents are discussed, alongside
anti-trypanosomatid heterocyclic compounds as structures for
development. Combining the expertise of specialists from around the
world, this volume aims to support and encourage researchers in the
investigation of natural sources as starting points for the
development of novel, safe and effective agents for use against
neglected tropical diseases.
Filling a gap in the scientific literature, Room Temperature
Organic Synthesis is unique in its authoritative, thorough, and
applied coverage of a wide variety of "green" organic synthetic
methodologies. The book describes practical, feasible protocols for
room temperature reactions to produce carbon-carbon and
carbon-heteroatom bond formations including aliphatic, aromatic,
alicyclic, heterocycles, and more. Consistently organized for easy
access, each selected reaction is discussed in a very compact and
structured manner including: reaction type, reaction condition,
reaction strategy, catalyst, keywords, general reaction scheme,
mechanism (in selected cases), representative entries, experimental
procedure, characterization data of representative entries, and
references. This book will be a valuable resource for synthetic
organic, natural products, medicinal, and biochemists as well as
those working in the pharmaceutical and agrochemical industry.
Green Synthetic Approaches for Biologically Relevant Heterocycles,
Second Edition, Volume Two: Green Catalytic Systems and Solvents
reviews this significant group of organic compounds within the
context of sustainable methods and processes, expanding on the
first edition with fully updated coverage and a whole range of new
chapters. Volume Two explores green catalytic systems and solvents
and the techniques surrounding this approach, including metal and
magnetic catalysis to organocatalysis and solid acid catalysis,
cycloaddition reactions, and varied approaches using ionic liquids.
This updated edition is an essential resource on sustainable
approaches for academic researchers, R&D professionals, and
students working across medicinal, organic, natural product and
green chemistry.
This book offers physical characteristics and spectral data of 150
selected natural compounds arranged according to their chemical
structures in various sub-classes. These include natural source,
molecular formula, chemical structure, physical characteristics
(melting point, molecular weight, and specific rotation) and
detailed spectral data (UV, FT-IR, 1H-NMR, 13C-NMR, 2D-NMR, Mass)
along with their assignments for each compound.
Cardioprotective Natural Products: Promises and Hopes focuses on
the recent advances in the research of bioactive natural products
with cardioprotective potential against various cardiovascular
diseases/disorders. The aim of this book is to underline the
promise and future hope in bioactive natural molecules, herbal
formulations, natural dietary supplements and related materials in
the prevention and cure of cardiovascular diseases in a scientific
way.This book, which comprises a variety of about 9 chapters
written by active researchers and leading experts, brings together
an overview of current discoveries and trends in this field. This
volume is also an outstanding source of information with regard to
the industrial application of natural products for medicinal
purposes. The broad interdisciplinary approach adopted in this book
ensures that it is much more interesting to scientists deeply
engaged in the research and/or use of bioactive natural products.
It will serve not only as a valuable resource for researchers in
their own fields to predict promising leads for developing
pharmaceuticals to prevent and treat disease manifestations, but
will hopefully also motivate young scientists to engage in the
dynamic field of natural products research.
NATURAL BIOACTIVE MOLECULES: Impacts and Prospects in Medicinal
Chemistry is an endeavor to underline how natural product research
continues to make significant contributions in the domain of
discovery and development of new medicinal entities. Natural
products present in the plant and animal kingdom offer a huge
diversity of chemical structures which are the result of
biosynthetic processes that have been modulated over the millennia
through genetic effects. Bioactive natural products are proving to
be a rich source of novel therapeutics. Search for bioactive
molecules from nature (plants, animals, microflora) continues to
play an important role in fashioning new medicinal agents. With the
advent of modern techniques, very particularly the rapid
improvements in spectroscopic as well as accompanying advances in
high-throughput screening techniques, it has become possible to
have an enormous repository of bioactive natural compounds, thus
opening up exciting new opportunities in the field of new drug
development to the pharmaceutical industry.This book, which will
comprise a variety of at least fifteen chapters written by active
researchers and leading experts in natural products chemistry on
biologically active natural products, brings together an overview
of current discoveries and trends in this remarkable field. This
definite volume is also an outstanding source of information with
regard to the industrial application of natural products for
medicinal purposes. The broad interdisciplinary approach dealt in
this book would surely make the work much interesting to the
scientists deeply engaged in the research and/or use of bioactive
natural products. It will serve not only as a valuable resource for
researchers in their own fields to predict promising leads for
developing pharmaceuticals to treat various ailments and disease
manifestations, but also motivates young scientists to the dynamic
field of bioactive natural products research.
Bioactive natural products are a rich source of novel therapeutics.
Thus, the search for bioactive molecules from nature continues to
play an important role in fashioning new medicinal agents. This
volume, which comprises sixteen chapters written by active
researchers and leading experts in natural products chemistry,
brings together an overview of current discoveries in this
remarkable field. It also provides information on the industrial
application of natural products for medicinal purposes. This book
will serve as a valuable resource for researchers to predict
promising leads for developing pharmaceuticals to treat various
ailments and disease manifestations.
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