This book is focused on a broader approach for all assurance providers (including both internal and external auditors) and addresses various advanced concepts that assurance providers need an understanding of.

Hardbound. Eminent scientists at the cutting edge of pharmacology and medicinal chemistry research provide us with yet another excellent addition to this famous series. The focus on bacterial resistance mechanisms serves to highlight an important area of unmet medical need requiring the attention of medicinal chemists.Five topical subjects are reviewed: the biosynthesis, metabolism and function of Vitamin D3 and the potential application of its analogues in bone disorders and immune-related diseases; the therapeutic potential of neurokinin antagonists; opioid receptor antagonists; the mechanisms of bacterial resistance; and a survey of recent advances in cannabinoid research.This volume will deservedly take its place in clinical and industrial pharmaceutical libraries, and will prove invaluable to medicinal chemists.

Hardbound. In this volume, there are five reviews of topical subjects. The availability of drugs for the successful treatment of many diseases results in an increase in the number of people who live to their eighties and nineties at which time Alzheimer's disease is most prevalent. The steady progress which is being made in our understanding of this complex disease and in the development of drugs for its treatment are reviewed in Chapter 1. Chemotherapy of another disease which often resists treatment may have another weapon in its armoury if recent work on modifying a naturally occurring anticancer compound (camptothecin) succeeds in reducing its side-effects; recent efforts in this field (described in Chapter 2) may yield a drug of value in treating cancer of the colon and stomach.Transporting a drug molecule to a specific site of action continues to present a challenge. The use of phosphates and phosphonates to protect the drug from hydrolysis or o

The question of what environmental statistics is about is particularly important when it comes to the formulation of relevant research and training, whether in academia, agencies, or industries. This volume aims to give a new perception on the subject with some examples that are of concern and interest today. Environmental statistics is in a take-off stage both for reasons of societal challenge and statistical opportunity, and is demanding more and more from non-traditional and innovative statistical approaches. The chapters in this volume, which are specially prepared by several outstanding professionals involved in statistics and the environment, discuss the current state of the art in diverse areas of environmental statistics. The volume provides new perspectives and problems for future research, training, policy and regulation. It will be valuable to researchers, teachers, consultants and graduate students in statistics, environmental statistics, statistical ecology, and quantitative environmental sciences in academia, industries, governmental agencies, laboratories and libraries.

A contemporary version of the story of David and Bathsheba. When David Samuel, chairman of Globe Oil, a multinational oil company, becomes a widower, his world is turned upside down. His old friend, Nathan - also a work colleague - and his wife have provided support and care for him, as has his friend and colleague, Rich Hampton. Rich has recently married the beautiful Beth. Then David notices a beautiful girl on a train and is very attracted to her. Later it becomes devastatingly clear that this is the new Mrs Hampton. David plans to get Rich out of the way by sending him on an assignment abroad, and begins an affair with his wife; but Beth becomes pregnant. When conscientious Rich won't return home, there's only one solution in David's mind. he has Rich murdered. Played against a strong backdrop of good supporting characters (including Beth's sister, Cerys, whose husband has an affair and leaves her), Beth ultimately loses the baby. But David has an epiphany; fasting for the child and the woman he loves, he meets with God. He is a chastened and changed man. Beth too has her own experience with God, and throws herself into charitable work. At the end, they come together again, different, but still in love.