This book provides practical, comprehensive knowledge on how to use the advances in analytical measurements and basic and advanced control to improve batch profiles and endpoint consistency. The consequential integration of measurements, models, and controls into a digital twin with recently developed blocks to provide profiles and predict endpoints enables: Developing dynamic models from trend charts that are used for experiment design, diagnosing the sources of limitations and inconsistences, and developing and testing solutions 500 times real time without interfering with existing plant operation. Comprehensive views of basic process control with the possibilities of model predictive control to control and optimize batch profiles by non-intrusive development and confirmation. The ability to determine how to maximize the performance of bioreactors, which are often the bottleneck and the key to product quality and consistency, without tests or trials in the actual plant. The resulting improvements in batch cycle time and consistency can be designed, tested, quantified, and confirmed; and operators can be trained independently of actual plant operation. The benefit from the elimination of a bad batch—particularly for new biologics—is potentially worth ten or more million dollars.

This book is a diamond in the rough and says ""forever"" if dipped in acrylic. It is not suitable as a gift for Domestic Companions. There are very few jokes at the expense of management. This book provides great preparation for the upcoming ""Automation Reality"" TV program. Twenty vendors and one ""user"" are locked in a room with 1000 PowerPoint slides - very similar to a local ISA meeting.In the end, it seems like Ted will slip in a cartoon of a female-type boss trying to convince him that ""discrete manufacturing"" is more important than his ethics or appearance.At the current time, this book will not be offered as an Educational Book Cartridge for the Leapster Multimedia Learning System Library.Warning from the Automator General - This book may cause uncontrollable laughter. Do not read this in combination with any other books by Stan and Greg.

Building on the knowledge and the goals of the best-selling book, Advanced Control portable pocket guide goes beyond theoretical concepts and provides new insight into implementation practices after the objectives have been defined and the technology been made. Recognizing the opportunity that models present to capture and exploit plant knowledge the authors share their expertise on the concepts, procedures and examples needed to construct apply different models through the use of ""state of the art"" software for simulation and predictive control. Sharing the results of the extensive testing they performed and to extend utility of Models Unleashed, the authors have included a Web site link that lets you down load Microsoft Excel spreadsheets and Powerpoint files. You don't need an advanced degree to get the most out of this pocket guide. Models help engineers closest to the application take advantage of their experience by embedding it in a model and a control system.