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The results of treatment for childhood acute myelogenous leukemia
(AML) have improved considerably during the last ten years. This
progress was demonstrated by the two consecutive multicenter
studies, AML-BFM-78 and -83, in which almost identical extended
multi drug regimes of che motherapy were administered for eight
weeks and followed up by two years maintenance. The main difference
in the second study was the addition of an eight-day intensive in
duction course. Due to this new element, the relapse rate was
reduced significantly. Another result of the BFM-83 study was the
definition of two risk groups on the basis of standardized
treatment, which has lead to a risk-adapted treatment strategy in
the third ongoing trial, AML-BFM- 87. This improvement was only
possible thanks to the coop eration of pediatricians, physicians,
radiotherapists, statisti cians, and especially the staff at the
hospitals and reference laboratories. Thus, we would like to thank
everyone who has been involved in these studies and hope that they
will be further encouraged to improve treatment strategies for AML
in children. The coordination, enforcement, and analyses of the
stud ies would not have been possible without the financial sup
port of the Federal Ministry for Research and Technology of the
FRG. We are grateful for the generous contributions supporting this
book from Lederle and Farmitalia. Munster, April 1990 Ursula
Creutzig Jorg Ritter Gunther Schellong Contents 1 Introduction . .
. . .. . . . . . . . . . . . . . . .. . . . 1 ."
Acute leukemia a quite homogenous disease failed to break through
the sound barriere of when untreated reveals a substantial hetero
unsatisfactory cure rates even in special sub geneity in its
response to therapy. While cure groups. While new protocols
including more is achieved in a certain proportion of pa effective
supportive care show some increase tients other cases prove to be
highly resis in the initial response rates and certain im tant. The
curability is superior in acute provements in the long-term
results, no ben lymphoblastic (ALL) than in acute myeloid eficial
effect on the relapse rate during the (AML) leukemia and - within
both type- first 1 Y2 years emerged from any of these higher in
children as compared to adults. regimens. Thus, high chances for
cure are The two age groups and cell types can be presently
restricted to children with ALL further subdivided into prognostic
groups and to lesser proportions children with by special
diagnostic features. Thus, in AML and adults with ALL and AML.
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