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This monograph is dedicated to one of the discoverers of poly(ADP
ribose), Professor Paul Mandel, from the Centre de Neurochimie in
Strasbourg. We would like to congratulate him for his distinguished
contributions to the field of poly(ADP-ribosyl)ation and express
our gratitude for his support in the last years and particularly
for his encouragement for the organization of this meeting.
Poly(ADP-ribose) was discovered more than 25 years ago. Since then,
excellent progress has been made on the study of the mechanisms of
poly(ADP ribose) reaction. The last five years have been
particularly exciting since the development of various molecular
biology techniques has revealed the complex nature of this
multifunctional enzyme. Looking at the contributions presented at
this meeting, it becomes obvious that more work at the molecular
level is needed. Most likely, these experiments will shed some
light on the functions of poly(ADP-ribose), but further iophysical
studies will still be required to fully understand this complex
enzymatic system."
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