Pharmacological and clinical research on nitrates continues to be of growing interest in many centers. This is surprising in view of the fact that their favorable effects in angina pectoris were described by Brunton and by Murrell in the Lancet more than 100 years ago. As expected, a host of new information has been collected since the two previous symposia on nitrates held in Stockholm in 1975 and Berlin in 1978. New insights were gained into the pharmacology, pharmacokinetics and pharmacodynamics of nitrates, as well as into their clinical effects in acute and chronic ischemic heart diseases and in severe congestive heart failure. Relatively little progress, however, was observed in research into the basic action of nitrates. Although most investigators agree that intracellular sequestration of calcium is probably the main mechanism by which nitrates lead to the reduction of vascular smooth muscle tone, the exact site of their action still remains undefined. In contrast, dose-dependent differences in venous and arteriolar tone have long been clearly established. Treatment was again in the main stream of discussion. The question of tolerance following long-term administration was discussed in depth and the term "pseudotolerance" was introduced to describe the adaptation of the body's circulatory system to chronic vasodilation. This is especially important in long term prophylactic antiischemic treatment in stable, as well as in unstable angina pectoris (i.e. during increased vasomotor tone - spasm).

Originally published in 1933, this volume contains the emended text of the Adamson Lecture for 1930, delivered by H. J. C. Grierson under the title 'Carlyle and the Hero'. This book will be of value to anyone with an interest in the modern and possibly controversial applications of Carlyle's philosophy.

This book puts preachnig into a South African context. It seeks to advance biblical preaching grounded in sound homiletic theory, but also matches theology and praxis. The book is designed as a guide to students of homiletics and those who have to preach a Sunday sermon week by week.

Join 4th Grade Scholars from Henry Johnson Charter School as they explore African American history through their writing and symbolic art!

This rhyming alphabet book (written by 3rd graders) describes the activities, choices, and rewards for children who work hard and do the right thing.

This book is an illustrated history of Henry Johnson and the 369th Infantry, nicknamed the "Harlem Hellfighters" of their time in France during World War I. This book was created by 3rd Grade Scholars from Henry Johnson Charter School in Albany, New York (home city of Henry Johnson).

This non-fiction frog species book was created by 3rd graders who researched, then illustrated a variety of real-world frogs.

Simplicius Simplicissimus - the towering achievement of H.J.C. von Grimmelshausen, one of the earliest novelists in the German language - charts the adventures of its hero, Simplicius, through the horrors of battle, murder, fire and famine, offering an invaluable eyewitness account of the Thirty Years' War and showing how humanity can, in the end, triumph over brutality A work of great poetical beauty and satirical strength, and a lasting historical document of timeless value, Simplicius Simplicissimus is one of the greatest picaresque novels in the Western canon.

Simplicissimus, which has more than once been called the greatest of all German novels, has a terrible relevance in the America of today, writes Eric Bentley in his preface to this edition. "For the Thirty Years' War, which is its subject, was not just any war. It was a war which inflicted death not on individuals only but on cities, on populations, and it was a war in which life went on, between battles, in the seventeenth-century equivalent of deep shelters protected from the neighbors by machine guns: a war which, even more than other wars, brought out the worst in human nature. And around it, as today, in supreme irony: the highest of high ideals." "There is great literature of war, and very much of it speaks poignantly today. The Simplicissimus may well be the most poignant book in all this literature because its war, alas, is our war, our kind of war. . . . At moments, the Simplicissimus may be too painful to read, and its relevance too much to bear thinking of, but it is a classic function of literature to make the unbearable bearable, the painful--and not perversely-pleasurable. There is a transcendence here, and in the case of the Simplicissimus, not just an aesthetic one. We shall not end the horrors of war by refusing to let the mind dwell on them."