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Founded by Alfred C. Kinsey in 1947, the Kinsey Institute has been
a leading organization in developing an understanding of human
sexuality. In this new book with over 65 images of Kinsey and the
Institute's collections, Judith A. Allen and the coauthors look at
the work Kinsey started over 70 years ago and how the Institute has
continued to make an impact on understanding on our culture.
Covering the early years of the Institute through the "Sexual
Revolution," into the AIDs pandemic of the Reagan era, and on into
the "internet hook-up" culture of today, the book illuminates the
Institute's work and its importance to society.
Thorough Overview Identifies and Addresses Critical Gaps in the
Treatment of Several Chronic Diseases With increasing numbers of
patients suffering from Immune-Mediated Inflammatory Diseases
(IMIDs), and with the increasing reliance on biopharmaceuticals to
treat them, it is imperative that researchers and medical
practitioners have a thorough understanding of the absorption,
distribution, metabolism and excretion (ADME) of therapeutic
proteins as well as translational pharmacokinetic/pharmacodynamic
(PK/PD) modeling for them. This comprehensive volume answers that
need to be addressed. Featuring eighteen chapters from
world-renowned experts and opinion leaders in pharmacology,
translational medicine and immunology, editors Honghui Zhou and
Diane Mould have curated a much-needed collection of research on
the advanced applications of pharmacometrics and systems
pharmacology to the development of biotherapeutics and
individualized treatment strategies for the treatment of IMIDs.
Authors discuss the pathophysiology of autoimmune diseases in
addition to both theoretical and practical aspects of quantitative
pharmacology for therapeutic proteins, current translational
medicine research methodologies and novel thinking in treatment
paradigm strategies for IMIDs. Other notable features include: -
Contributions from well-known authors representing leading academic
research centers, specialized contract research organizations and
pharmaceutical industries whose pipelines include therapeutic
proteins - Chapters on a wide range of topics (e.g.,
pathophysiology of autoimmune diseases, biomarkers in ulcerative
colitis, model-based meta-analysis use in the development of
therapeutic proteins) - Case studies of applying quantitative
pharmacology approaches to guiding therapeutic protein drug
development in IMIDs such as psoriasis, inflammatory bowel disease,
multiple sclerosis and lupus Zhou and Mould's timely contribution
to the critical study of biopharmaceuticals is a valuable resource
for any academic and industry researcher working in
pharmacokinetics, pharmacology, biochemistry, or biotechnology as
well as the many clinicians seeking the safest and most effective
treatments for patients dealing with chronic immune disorders.
Drug-drug interactions (DDIs) occur when a patient is exposed
simultaneously to multiple pharmaceuticals, which can result in
variations in drug response of the co-administered drugs. Using
illustrative case studies and examples, Drug-Drug Interactions for
Therapeutic Biologics focuses on the theoretical and practical
aspects of DDIs assessments for therapeutic biologics in drug
development. The book addresses the complex nature of biologic drug
development and DDIs, which are very different from more
traditional small molecule drugs, to help readers solve problems of
preclinical pharmacology, toxicology, and model-based approaches
for biologic drug development and the risk of drug-drug
interactions.
With an emphasis on the fundamental and practical aspects of ADME
for therapeutic proteins, this book helps readers strategize, plan
and implement translational research for biologic drugs. Details
cutting-edge ADME (absorption, distribution, metabolism and
excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling
for biologic drugs Combines theoretical with practical aspects of
ADME in biologic drug discovery and development and compares
innovator biologics with biosimilar biologics and small molecules
with biologics, giving a lessons-learned perspective Includes case
studies about leveraging ADME to improve biologics drug development
for monoclonal antibodies, fusion proteins, pegylated proteins,
ADCs, bispecifics, and vaccines Presents regulatory expectations
and industry perspectives for developing biologic drugs in USA, EU,
and Japan Provides mechanistic insight into biodistribution and
target-driven pharmacokinetics in important sites of action such as
tumors and the brain
This book covers a wide range of applications and uses of
simulation and modeling techniques in polymer injection molding,
filling a noticeable gap in the literature of design,
manufacturing, and the use of plastics injection molding. The
authors help readers solve problems in the advanced control,
simulation, monitoring, and optimization of injection molding
processes. The book provides a tool for researchers and engineers
to calculate the mold filling, optimization of processing control,
and quality estimation before prototype molding.
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