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Based on the international workshop GPCRs: From Deorphanisation
to Lead Structure Identification, held in Berlin in May 2006, the
book highlights the following topics: Structure of GPCRs, Design of
GPCR Ligands, GPCR Signalling, Deorphanization and Assay
Development. All chapters are written by leading experts in the
field, discussing the most recent state of the art. They give
insight into the approaches taken by industry and academia to
address GPCRs and depict how mature this target class-oriented
research has become in the last decade. The book reflects the
actual trends in the fast-emerging field of GPCR research in
academia and industry.
This book is a practical guide for the management of at-risk early
pregnancy. It is relevant to trainees in maternal-fetal medicine
and obstetrics, as well as nurses and sonographers who see many
at-risk patients in the early stages of pregnancy.
This multi-volume set within International Review of Cytology
encompasses the recent advances in the understanding of
structure-function relationships at the molecular level of
receptors, transporters, and membrane proteins. Several diverse
families of membrane receptors/proteins are discussed with respect
to the molecular and cellular biology of their synthesis, assembly,
turnover, and function. Included are such receptor superfamilies as
G-proteins, immunoglobulins, ligand-gated receptors, interleukins,
and tyrosine kinases as well as such transporter/protein families
as pumps, ion channels, and bacterial transporters. Each section of
each volume features a "perspectives/commentary" chapter which
includes comments on the recent advances and predictions on new
directions. Written by acknowledged experts in the field, this
volume, 137C, highlights recent developments in pumps, channels,
and transporters.
Key Features
* The latest on several important protein families, including:
* The G-protein-coupled receptors
* The interleukin receptors
* Sugar transporters
* Several ion channels and pumps
Problems in early pregnancy are among the most common conditions in
gynecology and - with management becoming less invasive and
depending more on accurate ultrasound and a good understanding of
serum biochemistry - many countries now recommend that all
maternity units have an early pregnancy section dedicated to
managing these conditions. In addition to this, the subject is also
an essential part of the training syllabus in the speciality of
maternal-fetal medicine. Handbook of Early Pregnancy Care is a
practical guide for the management of at-risk early pregnancy. The
chapters are concise, well-illustrated and contain decision trees
for the management of each condition. Focusing on practical
management, not just research, this helpful text will be beneficial
in the clinic, as contributors are encouraged to tell the readers
what to do in critical situations. Covering key points and
containing illustrative case studies, this handbook is relevant to
trainees in maternal-fetal medicine and obstetrics, as well as
nurses and sonographers who see many at-risk patients in the early
stages of pregnancy. Short Contents
Since the pioneering work of Donald and his first Lancet paper in
1958, the use of ultrasound in obstetrics and gynaecology has
evolved rap idly. The introduction of grey scale techniques
enhanced our ability to identify different tissues on the basis of
their texture. However, it was the introduction of the linear array
real-time scanner in the mid seven ties that changed ultrasound
from being an "eccentric art form" to a readily available and
usable technique. This led to the first reports of the diagnosis of
neural tube defects using ultrasound by Campbell, as well as the
establishment of fetal biometry. In the midst of this activity the
parallel development of the transvaginal probe by Kratochwill went
almost unnoticed by most gynaecologists. Yet the application of
this technique has since had a major impact on many areas of gyna
ecological practice, and on infertility in particular. Since the
demon stration of transvaginal follicle aspiration, the vaginal
route has become standard for most invasive ultrasound guided
gynaecological procedures. The relatively new technical advance of
transvaginal colour Doppler may potentially have just as great an
impact. The introduction and use of transvaginal colour flow
imaging has facili tated the study of vascular changes within the
pelvis.
Based on the international workshop GPCRs: From Deorphanisation
to Lead Structure Identification, held in Berlin in May 2006, the
book highlights the following topics: Structure of GPCRs, Design of
GPCR Ligands, GPCR Signalling, Deorphanization and Assay
Development. All chapters are written by leading experts in the
field, discussing the most recent state of the art. They give
insight into the approaches taken by industry and academia to
address GPCRs and depict how mature this target class-oriented
research has become in the last decade. The book reflects the
actual trends in the fast-emerging field of GPCR research in
academia and industry.
paper he discussed the results whim had been obtained from his
studies of the adrenal gland. The results he obtained are probably
best told in his own words: -"To see whether the adrenal cortex
contains any such reducing agent the gland was cut with a knife
into halves-which were immersed in a 0. 4% AgN0 solution. In a few
minutes the cortical part 3 was seen to darken through the
deposition of reduced metallic silver. In a quarter of an hour the
cut surface of the cortex turned completely black while the medulla
remained largely uncoloured. The black colouration ends towards the
medulla with a sharp margin, which corresponds to the anatomical
margin between the medulla and cortex. Like the medulla, other
organs, such as brain, liver and muscle remain practically
uncoloured. " When the gland was immersed in a mixture of potassium
iodate and acetic acid-a reagent for adrenalin, the medulla became
violet in colour and the cortex remained colourless. SZENT-GYORGYI
therefore came to the conclusion that: -"The adrenal cortex
therefore, contains some specific highly reducing agent which can
be no arte fact, since its action is produced in the almost fresh
material. " Methyl alcohol extracts of the cortex reduced neutral
silver nitrate almost instantaneously and when the portions of the
interrenal glands of Elasmobranm fishes were treated with silver
nitrate solutions they too went black-so that it appeared that this
highly reducing factor was a funda mental constituent of adrenal
tissue."
This book presents fundmentals of orbit determination--from
weighted least squares approaches (Gauss) to today's high-speed
computer algorithms that provide accuracy within a few centimeters.
Numerous examples and problems are provided to enhance readers'
understanding of the material.
*Covers such topics as coordinate and time systems, square root
filters, process noise techniques, and the use of fictitious
parameters for absorbing un-modeled and incorrectly modeled forces
acting on a satellite.
*Examples and exercises serve to illustrate the principles
throughout each chapter.
*Detailed solutions to end-of-chapter exercises available to
instructors.
This Is A New Release Of The Original 1908 Edition.
This Is A New Release Of The Original 1909 Edition.
This Is A New Release Of The Original 1908 Edition.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ The Father Revealed And Christ Glorified an Exposition Of John
Xvii]. Henry H. Bourn
This is an EXACT reproduction of a book published before 1923. This
IS NOT an OCR'd book with strange characters, introduced
typographical errors, and jumbled words. This book may have
occasional imperfections such as missing or blurred pages, poor
pictures, errant marks, etc. that were either part of the original
artifact, or were introduced by the scanning process. We believe
this work is culturally important, and despite the imperfections,
have elected to bring it back into print as part of our continuing
commitment to the preservation of printed works worldwide. We
appreciate your understanding of the imperfections in the
preservation process, and hope you enjoy this valuable book.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ Earth's Diamonds; Or, Coal, Its Formation And Value Henry H.
Bourn S.W. Partridge, 1882
THIS 22 PAGE ARTICLE WAS EXTRACTED FROM THE BOOK: Life of the
Universe Part 1, by Svante Arrhenius. To purchase the entire book,
please order ISBN 076612911X.
The Book That Contains Arrhenius' Panspermic Theory Of The Origins
Of Life On Earth - I.e. That Living Seeds, Spores, Etc. Could Be
Transported From Interstellar Space By The Pressure Of Light.
THIS 40 PAGE ARTICLE WAS EXTRACTED FROM THE BOOK: Life of the
Universe Part 1, by Svante Arrhenius. To purchase the entire book,
please order ISBN 076612911X.
This scarce antiquarian book is a selection from Kessinger
Publishing's Legacy Reprint Series. Due to its age, it may contain
imperfections such as marks, notations, marginalia and flawed
pages. Because we believe this work is culturally important, we
have made it available as part of our commitment to protecting,
preserving, and promoting the world's literature. Kessinger
Publishing is the place to find hundreds of thousands of rare and
hard-to-find books with something of interest for everyone!
THIS 22 PAGE ARTICLE WAS EXTRACTED FROM THE BOOK: Life of the
Universe Part 1, by Svante Arrhenius. To purchase the entire book,
please order ISBN 076612911X.
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