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An International Symposium "Catecholamines and the Heart" was held
in Munich in May 1981, which was organized in cooperation with the
Council on Cardiac Metabolism of the International Society and
Federation of Cardiology and with the Microcirculation Working
Group of the European Society of Cardiology. It was the aim of the
organizers to evaluate in this Symposium the recent advances made
in the field of sympathetic control of heart function. Particular
attention was given to neural sympathetic pathways, to mechanisms
and consequences of adrenoceptor stimulation and blockade as well
as to clinically relevant implications mainly regarding the
significance of catecholamines and of adrenoceptors in various
heart diseases. The broad scope was covered in 34 papers presented
by physiologists, pharmacologists and cardiologists during a two
day meeting which was attended by an international audience. This
book includes all papers as well as the discussions following each
presentation. To accomplish rapid publication the manuscripts are
published as submitted by the authors. The discussions were edited
making use of the written questions and answers of the discussants.
The Symposium was generously sponsored by Astra Chemicals GmbH,
Wedell Holstein, Germany, which thus made possible a very fruitful
exchange of information, ideas and concepts between specialists in
various disciplines. The organizers gratefully acknowledge this
support once again and would like to thank Dr. T. Kreuzer, the
representative of Astra Chemicals, for his personal engagement.
This volume is the product of a symposium held on 14-16 February,
1985 in Ham- burg in honour of the 65th birthday of Prof.
Hans-Joachim Schumann. Schumann was born on 28 December, 1919 in
Stralsund. He studied medicine in Cologne, Greifswald and Rostock.
The chair of pharmacology in Rostock was held at that time by Peter
Holtz. It was he who first introduced Schumann to pharma- cology in
1944 and who was his Doktorvater (research supervisor). Mter the
war, Schumann again worked with Holtz in Rostock and then in
Frankfurt am Main. He received decisive stimuli during a research
fellowship, in 1956, in Prof. J. H. Burn's department in Oxford,
where he also worked with Prof. H. Blaschko. In 1964 he ac- cepted
his present position as ordentlicher (full) Professor and Head of
the Institute of Pharmacology and Toxicology of the then newly
founded Medical Faculty of Es- sen. He has remained in Essen
despite being offered the chair of pharmacology in G6ttingen in
1968. It is interesting to observe how in the main lines of his
scientific work, which now spans 40 years, Schumann has followed
the steps involved in autonomic neuro- transmission from
transmitter release to transmitter-receptor interaction.
In the last decade, ACE inhibitors have become a cornerstone of
cardiovascular drug therapy. Beneficial effects in patients with
hypertension, heart failure, and post myocardial infarction have
been established in large clinical trials. In parallel, ex
perimental research has shifted the interest from the immediate
homeostatic function of the circulating renin-angiotensin-system to
the multiple paracrine functions of local tissue
renin-angiotensin-systems, including hypertrophy, hyperplasia,
athe- oenesis, and vasomotion. . It was the aim or a symposium held
in Hamburg, October 22-24, 1992, to bring together an international
panel of experimental and clinical scientists and to discuss the
most recent findings on the role of angiotensin and associated
mediators in car diovascular adaptation and disease, with a
particular emphasis on the treatment of such disease by ACE
inhibitors. The meeting and this publication were generously
supported by Astra Chemicals. H. Grobecker G. Heusch B. E. Strauer
Contents Foreword. . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . V
Introduction Local expression and pathophysiological role of
renin-angiotensin in the blood vessels and heart Dzau, V. J. . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 1 Myocardial Perfusion Angiotensin,
ACE-inhibitors and endothelial control of vasomotor tone Luscher,
T. F. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . 15 Local and
neurohumoral control of coronary blood flow Krajcar, M., G. Heusch.
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 25 ACE-inhibitors in coronary artery disease?
Vogt, M., W. Matz, B. E. Strauer . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 43 Myocardial Hypertrophy
Molecular mechanisms of cardiac gene expression Nadal-Ginard, B.,
V. Mahdavi . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 65 Myocardial perfusion dependent and independent
mechanisms of regional myocardial dysfunction in hypertrophy
Vatner, S. F., L. Hittinger . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . ."
In den letzten Jahren haben Hemmstoffe des Konversionsenzyms bei
der Indikation hoher Blutdruck, Herzinsuffizienz und bei Zustanden
nach Myokardinfarkt eine Dif- ferentialtherapie erlaubt, die in
ihren Ergebnissen bemerkenswert ist und uber eine Organ protektion
zur Senkung der Mortalitat dieser letalen kardiovaskularen
Erkrankungen beigetragen haben. Experimentelle Untersuchungen haben
die Bedeutung der organstandigen Renin-Angiotensin-Systeme
hervorgehoben und neue Aussichten zur Behandlung der Hypertrophie
des Herzens und der Arteriosklerose der Gefasse eroeffnet. Im hier
vorliegenden Band, in englisch erschienen als Supplement der
Zeitschrift Basic Research in Cardiology, werden die Vortrage eines
Internationalen Sym- posiums in Hamburg vom 22. bis 24. Oktober
1992 in deutscher UEbersetzung zusammengefasst. Der
interdisziplinare Charakter des Symposiums kommt in ex-
perimentellen und klinischen Untersuchungen zum Ausdruck. Die
Herausgeber hof- fen, dass das Symposium "Angiotensin and the
Heart" sich stimulierend auf die Grundlagenforschung und die
Behandlung von kardiovaskularen Erkrankungen mit Hemmstoffen des
Konversionsenzyms auswirkt. Das Symposium und seine Publikation
wurde grosszugig von der Firma Astra Chemieals, Wedel/Holstein,
unterstutzt. Unser besonderer Dank gilt Herrn Dr. Kreuzer und
seinen Mitarbeitern fur hilfreiche Diskussionen. H. Grobecker G.
Heusch B. E. Strauer Inhaltsverzeichnis Vorwort..... . . ....... .
...... . .... . . ..... . ..... ..... ...... . ..... V Einleitung
Lokale Expression und pathophysiologische Rolle von
Renin-Angiotensin im Gefasssystem und im Herzen Dzau, V. 1.
.................................................... .
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