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The methods of molecular biology, biochemistry, immunocytochem
istry, and in-situ hybridization introduce new opportunities for
the classification and functional characterization of cell
receptors under normal conditions and for a better understanding of
pathogenetic mechanisms in human diseases. The cellular
localization and trans location of receptor proteins can be
identified using morphological methods, and it is apparent that
receptors and receptor defects play an important role in pathology,
notably in genetic diseases, endocrine disorders, atherosclerosis,
infections, and cancer. In this volume in ternational experts give
a current review of the morphology and pathological aspects of cell
receptors. The complex communication of multicellular organisms is
coordi nated by two regulatory systems: neural and humoral. Both
systems function via signaling substances (ligands) and
signal-recognizing and -transmitting molecules, called receptors.
The historical develop ment of the receptor concept is based upon
Paul Ehrlich's theory of "receptors in the immune system,"
Langley's "receptive substances in postssynaptic membranes," and
Earl Sutherland's discovery of "sec ond messengers" (cAMP and
Ca2])."
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