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This two week course on Arterial Pollution covered the field of
atherosclerosis as a disease entity, and includes its anatomical,
physiopathological, epidemiologic, preventi ve and therapeutic
aspects. With the cooperation of an outstanding group of inter
national lecturers we have been able to present an overview of the
disease and its accidents as it stands today. Such a scope differs
greatly from the narrow workshops which only consider biochemical
disorders, e.g., the lipoproteins or the risk factors. We believe
it was timely to study the entire physiopa thological entity of
arterial pollution and we included all aspects of the disease in
one single sweep. We are grateful to the Nato Advanced Institute
Programs for accepting this topic on the list of their sponsored
initiatives and especially Mr. di Lullo for his personal care.
Whether we succeeded was proved by the audience to the Nato
Advanced Study Institute at Maratea in September 1981 and will
become clearer through the audience these proceedings will gain in
the medical community. H. Peeters, editor A. Gresham, R. Paoletti,
co-editors v CONTENTS An Integrated View on Atherosclerosis . * . .
. . . . . .. . 1 H. Peeters 1. NATURAL HISTORY 1.1.
Atherosclerosis: Its Origin and Development in Man. . 7 G.A.
Gresham 1.2. Functional Aspects of Atherogenesis. * . . . . . 23 .
K.W. Walton 2. ANIMAL MODELS 2.1. Animal Models of Atherosclerosis.
. * . . . . . . 55 .
A symposium was centered around the unsaturated phosphatidyl-
choline molecule and organized in order to assemble and coordi-
nate theoretical views with facts and results. The presence of a
high percentage of essential fatty acids in unsaturated phos-
phatidylcholine gave rise to the essential phospholipid concept. An
overview of the biological significance of phospholipids and a
review of a specific phosphatidylcholine-related enzyme, namely
LCAT or lecithin cholesterol acyl transferase, open these
proceedings. The simultaneous use of the synonyms - leci- thin and
phosphatidylcholine - was solved throughout the pub- lished
material by a preferential use of the more precise che- mical
terminology of phosphatidylcholine. A set of papers centered around
the pharmacology of polyunsa- turated phosphatidylcholine (PU-PC)
or essential phospholipids (EPL) is followed by reports on its
therapeutic effects. Further papers deal with the metabolism of the
arterial wall and the presence of phospholipid related enzyme
systems. Some hemody- namic related effects are dealt with in the
last section. These proceedings could be edited within a few months
thanks to the active cooperation of the authors. The editors are
grateful to acknowledge this rather unusual performance which tends
to prove the interest of all participants in this sym- posium. It
seems logical to presume that the topic itself is an important one
and that the meeting was timely organized.
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