Contents: R.L. Moss, G.M. Diffee, M.L. Greaser: Contractile Properties of Skeletal Muscle Fibers in Relation to Myofibrillar Protein Isoforms.- J.E. Wilson: Hexokinases.- J. Rassow, N. Pfanner: Molecular Chaperones and Intracellular Protein Translocation.- H. Fuder, E. Muscholl: Heteroreceptor-Mediated Modulation of Noradrenaline and Acetylcholine Release from Peripheral Nerves.

Discussions about reducing the harms associated with drug use and antidrug policies are often politicized, infused with questionable data, and unproductive. This paper provides a nonpartisan primer on drug use and drug policy in the United States. It aims to bring those new to drug policy up to speed and provide ideas to researchers and potential research funders about how they could make strong contributions to the field.

U.S. demand for illicit drugs creates markets for Mexican drug- trafficking organizations (DTOs) and helps foster violence in Mexico. This paper examines how marijuana legalization in California might influence DTO revenues and the violence in Mexico.

Legalizing marijuana in California would lead to a major decline in the pretax price, but the price for consumers will depend heavily on taxes, the regulatory regime structure, and how taxes and regulations are enforced. The lower price and nonprice effects will increase consumption, but it is unclear by how much. There is much uncertainty about the effect on public budgets; even minor changes in assumptions lead to major differences in outcomes.