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In aerobic tissues such as heart, brain, kidney, liver and brown
fat, mitochon- dria account for more than 20% of cell protein and
play an essential role in res- piration, ATP formation,
ketogenesis, gluconeogenesis, amino acid metabolism, ureagenesis,
thermogenesis and a variety of other metabolic activities. The
mecha- nisms by which these activities are integrated and regulated
within the overall context of cellular physiology is of much
current research interest. In order to bring together scientists
examining the various diverse aspects of this overall pro- blem, an
International Conference on INTEGRATION OF MITOCHONDRIAL FUNC- TION
was held June 4-7, 1987 at the Hanes Art Center on the campus of
the Uni- versity of North Carolina at Chapel Hill. The chapters of
this volume derive from presentations made at this conference. The
focus of INTEGRATION OF MITOCHONDRIAL FUNCTION is on signifi- cant
new experimental and theoretical advances concerning integration of
mito- chondrial function at the organelle, cell, tissue and whole
organism levels of organization.
In aerobic tissues such as heart, brain, kidney, liver and brown
fat, mitochon- dria account for more than 20% of cell protein and
play an essential role in res- piration, ATP formation,
ketogenesis, gluconeogenesis, amino acid metabolism, ureagenesis,
thermogenesis and a variety of other metabolic activities. The
mecha- nisms by which these activities are integrated and regulated
within the overall context of cellular physiology is of much
current research interest. In order to bring together scientists
examining the various diverse aspects of this overall pro- blem, an
International Conference on INTEGRATION OF MITOCHONDRIAL FUNC- TION
was held June 4-7, 1987 at the Hanes Art Center on the campus of
the Uni- versity of North Carolina at Chapel Hill. The chapters of
this volume derive from presentations made at this conference. The
focus of INTEGRATION OF MITOCHONDRIAL FUNCTION is on signifi- cant
new experimental and theoretical advances concerning integration of
mito- chondrial function at the organelle, cell, tissue and whole
organism levels of organization.
Systems biology is a vigorous and expanding discipline, in many
ways a successor to genomics and perhaps unprecedented in its
combination of biology with a great many other sciences, from
physics to ecology, from mathematics to medicine, and from
philosophy to chemistry. Studying the philosophical foundations of
systems biology may resolve a longer standing issue, i.e., the
extent to which Biology is entitled to its own scientific
foundations rather than being dominated by existing philosophies.
* Answers the question of what distinguishes the living from the
non-living
* An in-depth look to a vigorous and expanding discipline, from
molecule to system
* Explores the region between individual components and the system
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