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Current evidence indicates that over two-thirds of mood disorders
pursue a recurrent or chronic course. Yet much of the progress
recorded in the field of mood disorders and their treatment has
been in research into the acute phase of the illness. Hence there
is a need for a volume that specifically addresses the special
clinical problems encountered inthe recurrent forms of these
disorders. The various chapters of this book embrace a wide range
of topics, including etiology, course, and long-term treatment,
integrative reviews, results of recent investigations, and clinical
reports. In this respect, the contributions reflect
currentconcepts, research, and clinical practice. We have
endeavored to build a bridge between neurobiology and psychology
and have covered both the psychotherapeutic and the
psychopharmacologic aspects of mood disorders.
In this book we present a conceptually integrated approach to
disorders of mood. These disorders are defined narrowly as the
clinical syndromes of mania and melancholia. The latter is our
particular focus, for the simple reason that it is more common and
thus more is known about it. Our approach owes much to Adolf Meyer,
who first used the term psychobiology. It was he who emphasized in
a practical way the importance of the clinician consider ing the
joint contribution of psychosocial and biological factors in the
genesis of mental disorders. However, until the 1960s, our relative
ignorance of basic mechanisms that link brain and behavior
prevented the development of a genuine psychobiological
perspective. Thus Meyer's work was concerned largely with teaching
the importance of the personal biography and a consideration of
social history in the development of mental disorder. We feel that
sufficiently rigorous data have now emerged in psychia try to
permit tentative but real psychobiological integration. Affective
illness is proba bly the most promising area for an attempt at such
a synthesis. It is our belief that the theory and clinical practice
of psychiatry now can be woven into a coherent theme, integrating
insights and evidence generated by the psychodynamic, biological,
and behavioral methods; hence in part we review the emerging
psychobiology of mood disorders with the hope that it can serve as
a generic paradigm for other psychiatric syndromes."
Many clinicians and researchers are convinced that there is an
overlap between affective and schizophrenic spectra. In this book,
an international team of experts discuss aspects of comorbidity,
genetic models, clinical course, phenomenology and therapies. This
is the first comprehensive overview of the schizoaffective spectra.
Challenging cases presenting clinical and paraclinical features of
both spectra are surprisingly numerous. Not only the phenomenology
but also the course, outcome and treatment of such cases have their
own characteristics. Recent research shows that the overlap also
involves genetics and biological processes related to psychotic
disorders. Within the overlap of affective and schizophrenic
spectra it is possible to identify some groups of disorders having
similar clinical and non-clinical features: the 'schizoaffective'
group, 'Acute and Transient Psychotic Disorder' or 'Brief
Psychosis', and other groups found in so-called 'Atypical Forms'.
Many clinicians and researchers are convinced that there is an
overlap between affective and schizophrenic spectra. In this book,
an international team of experts discuss aspects of comorbidity,
genetic models, clinical course, phenomenology and therapies. This
is the first comprehensive overview of the schizoaffective spectra.
Challenging cases presenting clinical and paraclinical features of
both spectra are surprisingly numerous. Not only the phenomenology
but also the course, outcome and treatment of such cases have their
own characteristics. Recent research shows that the overlap also
involves genetics and biological processes related to psychotic
disorders. Within the overlap of affective and schizophrenic
spectra it is possible to identify some groups of disorders having
similar clinical and non-clinical features: the 'schizoaffective'
group, 'Acute and Transient Psychotic Disorder' or 'Brief
Psychosis', and other groups found in so-called 'Atypical Forms'.
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