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It can honestly be said that the scope and magnitude of this
meeting surpassed initial expectations with respect to the number
and quality of the papers presented. Our group has grown since we
last met in Dortmund in 1971. This is a good indication that a
spiraling of our interests has taken place with the effects of the
initial good work felt, not just in one corner of the globe, but in
all four. With such a start, it was only appropriate that an
international society was formed at the meeting to further
coordinate our mutual undertaking. Henceforth it shall be known as
the International Society of Oxygen Transport to Tissue. A final
note of acknowledgement should be made to those who were in the
supporting cast, not only in making the meeting in Charleston and
Clemson a success, but also in the compiling of this book.
Gratitude is due to Dr. Daniel H. Hunt for his efforts, the end
product of which you have in your hands. Considerable service was
rendered by Mr. Robert J. Adams, Mr. Buddy Bell and Mr. Nathan
Kaufman during the symposium itself. Much typing, organizing and
record keeping was done by our lovely secretaries, Laura B. Grove,
Muff Graham and Kaye Y. Zook.
Hyperthennia is rapidly becaning the fourth IIDdality of cancer
treatment, at least a useful adjuvant to radiation therapy, chEfiO
therapy or surgery; at best, a new therapeutic fonn that, properly
used, may open new horizons in the fight against this dreadful
disease. The staging is still primitive. The devices used are after
laboratory irrprovisations, and lack the precision and definition
of treatment fields that will allow mass use of the m: Xiality.
Clinical practices are limited to the procedural evaluations of a
few pioneer groups, and basic understanding of its mechanism of
action, although progressing by leaps and bounds, is still short of
perfection. The challenge and the pranise are there and because of
this, p engineers, physicists, biologists, physiologists and
clinicians fran different specialties have a basic need for
interaction, both in tenus of exchange of scientific infonnation
and peer review of results and clinical trials. To satisfy this
need, to act as a clearinghouse of knowledge and a fonnn for
discussion, the North Alrerican Hyperthennia Group (NAHG) has been
fonned. The reeting in Detroit in August 1981 represents the first
gathering of the group, to be followed by a second in Salt Lake
City in April 1982."
These papers stem from the ISOTT Meeting held at Churchill College,
Cambridge, from July 27th to 30th, 1986. Although the sun did not
shine so brightly as during the Cambridge meeting in 1977, the
communications and discussions were as lively and informative and
some heat, as well as light, was generated in the presentation of
differing views. The meeting was conducted in a generally informal
way which allowed maximum time for discussion but the relatively
unstructured nature of the debates made them unsuitable for
publication. The amount of editing necessary meant that the printed
version of the exchanges would bear little resemblance to the
original, hence their omission. All the papers presented here have
been scrutinized and retyped in a standard format. However, the
diverse interests of ISOTT's members, reflected in the wide
spectrum of the material submitted, made total editorial uniformity
an unrealistic goal. Complete consistency in the use of symbols,
abbreviations and units seemed less important than speed of
publication.
The International Society on OXygen Transport to Tissue (ISO'IT)
has canpleted nine years as a society since its first fonnal
meeting at Charleston-Clanson, South Carolina, United States of
America in 1973. Prior to this time an active group of scientists
and engineers rret in w:: >rkshop environrrents, on a periodic
basis, around the w:: >rld. Meetings are ncM on an annual basis,
alternating between Europe and the United States. The international
gatherings include scientists and engineers in a variety of fields.
ISOIT has produced a stable forum for the exchange of info: rmation
on the rnicroenvirornnent of living cells, ranging fran the
utilization of mathematics and engineering, through physiology and
radiobiology, to clinical applications. The proceedings of these
meetings have been codified into six books, four of them published
by Plenum Press in its prestigious Advances in Experimental
Medicine and Biology series. This volume, together with the next
two volumes that will follCJV.l the meetings in Dortmund, Gennany
in 1982 and in Ruston, Louisiana in 1983 will provide further
chapters in the history of this fascinating field of knCJV.lledge.
OUr thanks are given to all the participants and contributors to
the Detroit meeting. We hope that the strength of the society will
grow in caning years, and that our contribution will eventually be
felt in: inproving the treatment of the sick, and in enhancing the
thought processes of the intellectual.
Hyperthermia as a safe and effective cancer treatment modality is
rapidly evolving propelled by widespread research and clinical
efforts worldwide. Presentations on Hyperthermia experience are now
commonplace at Oncology meetings, as are congresses dedicated
entirely to the intertwined interactions between basic sciences and
patient treatment that together are forming the structure of a new
medical specialty. Such was the XII International Symposium on
Clinical Hyperthermia held in Rome, Italy, April 27 - 29, 1989.
Papers presented therein constitute the backbone of this book.
Biology research has provided data describing mechanisms of action
for the cancer cell killing and physiological effects of
Hyperthermia. Physics research has led to the development of
equipment enabling treatment of many areas of the human body, as
well as explained the limitations that still constrain our ability
to treat, especially in the areas of deep seated tumor heating and
non-invasive thermometry. The main question that will decide the
future of this modality is that of its clinical use. To put it
succinctly, what do we do with this potentially useful tool in an
everyday clinical oncological practice . ** ? This is the main
question addressed in this book as "Consensus on Hyperthermia for
the 1990s. " The book in cludes 28 presented papers and 25 invited
chapters from some of the leading experts in the field. Their basic
mechanisms of action were physics principles, treatment quality
assurance and especially, clinical indications.
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