This book constitutes the refereed proceedings of the 6th International Conference on Geo-informatics in Sustainable Ecosystem and Society, GSES 2018, held in Handan, China, in September 2018. The 46 papers presented in this volume were carefully reviewed and selected from 153 submissions and focus on spatial data acquisition, processing and management, modeling and analysis, and recent applications in the context of building healthier ecology and resource management using advanced remote sensing technology and spatial data modeling and analysis.