Colostrum, the first lacteal secretion in all mammals, is not only a good source of nutrients, but also contains many biologically active substances which play an important role in the protection and development of the newborn. However, colostrum composition and quality are affected by many factors including the preservation methods. It is useful to establish a colostrum bank to be used for newborn calves that cannot be fed by their own mother immediately after birth. Moreover, the bank can be used for preparation of colostral based products for the prevention and, to some extent, for the treatment of specified human diseases. This book aims to follow the changes in colostrum properties, colostrum preservation as well as evaluation of the safety of long-term colostrums consumption.