This book constitutes the proceedings of the 17th International Conference on Research Challenges in Information Sciences, RCIS 2023, which took place in Corfu, Greece, during May 23–26, 2023. It focused on the special theme "Information Science and the Connected World".The scope of RCIS is summarized by the thematic areas of information systems and their engineering; user-oriented approaches; data and information management; business process management; domain-specific information systems engineering; data science; information infrastructures, and reflective research and practice. The 28 full papers presented in this volume were carefully reviewed and selected from a total of 87 submissions. The book also includes 15 Forum papers and 6 Doctoral Consortium papers. The contributions were organized in topical sections named: Requirements; conceptual modeling and ontologies; machine learning and analytics; conceptual modeling and semantic networks; business process design and computing in the continuum; requirements and evaluation; monitoring and recommending; business process analysis and improvement; user interface and experience; forum papers; doctoral consortium papers. Two-page abstracts of the tutorials can be found in the back matter of the volume.