This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.

Due to the role of software systems in safety-critical applications and in the satisfaction of customers and organizations, the development of efficient software engineering is essential. Designing, Engineering, and Analyzing Reliable and Efficient Software discusses and analyzes various designs, systems, and advancements in software engineering. With its coverage on the integration of mathematics, computer science, and practices in engineering, this book highlights the importance of ensuring and maintaining reliable software and is an essential resource for practitioners, professors and students in these fields of study.

This new volume familiarizes readers with the very relevant concepts of human resources and finance in Industry 4.0. The book looks at the adoption of current fast-moving computers and automation in the workplace and its impact on the financial aspects of human resources and how HR can be enhanced with smart and autonomous systems fueled by data and machine learning. The chapters offer case studies that provide firsthand knowledge of real-life problems, solutions, and situations faced by the industry. The volume highlights the thought process in resolution of the complex problems. Topics include HR management approaches, global HR challenges, behavioral finance for financial acumen, corporate social responsibility, women empowerment in the HR industry, emotional intelligence in the era of Industry 4.0, and more.

The applications of nanoparticulate drug delivery have gained significant attention in cancer diagnosis and treatment. Owing to their unique features and design, nanomedicines have made remarkable progress in eliminating dreadful tumors. Research in cancer nanomedicine spans multitudes of drug-delivery systems that include high tumor-targeting ability, sensitivity toward tumor microenvironments, and improved efficacy. Various nanocarriers have been developed and approved for anti-tumor drug targeting. These nanocarriers, such as liposomes, micelles, nanotubes, dendrimers, and peptides, offer several advantages including high selectivity, multifunctionality, specificity, biocompatibility, and precise control of drug release. This book provides complete information about each aspect of nanomaterials and nanotherapeutics, including synthesis, analysis, disease diagnosis, mechanistic insight, targeted drug delivery, and clinical implications in a concise and informative way. It presents simple and reader-friendly representations of the mechanisms of action of nanomaterials on cellular targets and highlights the challenges in targeted drug delivery with ongoing chemotherapeutic drugs.

Exploring the issue of Islamophobic attacks against Sikhs since 9/11, this book explains the historical, religious and legal foundations and frameworks for understanding race hate crime against the Sikh community in the UK. Focusing on the backlash that Sikhs in the UK have faced since 9/11, the authors provide a theological and historical backdrop to Sikh identity in the global context, critically analysing the occurrences of Islamophobia since 9/11, 7/7 and most recently post-Brexit, and how British Sikhs and the British government have responded and reacted to these incidents. The experiences of American Sikhs are also explored and the impact of anti-Sikh sentiment upon both these communities is considered. Drawing on media reporting, government policies, the emerging body of inter-disciplinary scholarship, and empirical research, this book contributes to the currently limited body of literature on anti-Sikh hate crime and produces ideas for policy makers on how to rectify the situation. Providing a better understanding of perceptions of anti-Sikh sentiment and its impact, this book will of interest to scholars and upper-level students working on identity and hate crime, and more generally in the fields of Religion and Politics, Cultural Studies, Media Studies, and International Studies.

This important volume provide a one-stop resource on the SAFER Guides along with the guides themselves and information on their use, development, and evaluation. The Safety Assurance Factors for EHR Resilience (SAFER) guides, developed by the editors of this book, identify recommended practices to optimize the safety and safe use of electronic health records (EHRs). These guides are designed to help organizations self-assess the safety and effectiveness of their EHR implementations, identify specific areas of vulnerability, and change their cultures and practices to mitigate risks. This book provides EHR designers, developers, implementers, users, and policymakers with the requisite historical context, clinical informatics knowledge, and real-world, practical guidance to enable them to utilize the SAFER Guides to proactively assess the safety and effectiveness of their electronic health records EHR implementations. The first five chapters are designed to provide readers with the conceptual knowledge required to understand why and how the guides were developed. The next nine chapters focus on the underlying informatics concepts, key research activities, and methods used to develop each of the guides. Each of these chapters concludes with a copy of the guide itself. The final chapter provides a vision for the future and the work required to ensure that future generations of EHRs are designed, developed, implemented, and used to improve the overall safety of the EHR-enabled healthcare system. Taken together, the information provided in this book should help any organization, whether large or small, implement its EHR program and improve the safety and effectiveness of its existing EHR-enabled healthcare systems. This volume will be extremely valuable to small, ambulatory physician practices and larger outpatient settings as well as for hospitals and professors and instructors charged with teaching safe and effective implementation and use of EHRs. It will also be highly useful for health information technology professionals responsible for maintaining a safe and effective EHR and for clinical and administrative staff working in EHR-enabled healthcare systems.

Exploring the issue of Islamophobic attacks against Sikhs since 9/11, this book explains the historical, religious and legal foundations and frameworks for understanding race hate crime against the Sikh community in the UK. Focusing on the backlash that Sikhs in the UK have faced since 9/11, the authors provide a theological and historical backdrop to Sikh identity in the global context, critically analysing the occurrences of Islamophobia since 9/11, 7/7 and most recently post-Brexit, and how British Sikhs and the British government have responded and reacted to these incidents. The experiences of American Sikhs are also explored and the impact of anti-Sikh sentiment upon both these communities is considered. Drawing on media reporting, government policies, the emerging body of inter-disciplinary scholarship, and empirical research, this book contributes to the currently limited body of literature on anti-Sikh hate crime and produces ideas for policy makers on how to rectify the situation. Providing a better understanding of perceptions of anti-Sikh sentiment and its impact, this book will of interest to scholars and upper-level students working on identity and hate crime, and more generally in the fields of Religion and Politics, Cultural Studies, Media Studies, and International Studies.

This book explores potential cellular drug targets for cancer therapy. The first couple of chapters describe conventional treatment (radiotherapy, chemotherapy, and immunotherapy) & detection (biosensors) strategies for cancer. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment. The book then discusses the regulation of various pro-apoptotic and anti-apoptotic proteins via chemotherapeutic drugs. In addition, it examines the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells. It subsequently reviews the role of reactive oxygen (ROS) species during carcinogenesis and during chemotherapy, and the potential of anti-inflammatory routes for the development of new therapeutic modulators. Lastly, it describes therapeutic strategies that target the tumor microenvironment and various angiogenic pathways for the treatment of cancer and to develop personalized medicine. Given its scope, the book is valuable resource for oncologists, cancer researchers, clinicians, and pharmaceutical industry personnel.

This new volume familiarizes readers with the very relevant concepts of human resources and finance in Industry 4.0. The book looks at the adoption of current fast-moving computers and automation in the workplace and its impact on the financial aspects of human resources and how HR can be enhanced with smart and autonomous systems fueled by data and machine learning. The chapters offer case studies that provide firsthand knowledge of real-life problems, solutions, and situations faced by the industry. The volume highlights the thought process in resolution of the complex problems. Topics include HR management approaches, global HR challenges, behavioral finance for financial acumen, corporate social responsibility, women empowerment in the HR industry, emotional intelligence in the era of Industry 4.0, and more.

Despite diagnosis being the key feature of a physician's clinical performance, this is the first book that deals specifically with the topic. In recent years, however, considerable interest has been shown in this area and significant developments have occurred in two main areas: a) an awareness and increasing understanding of the critical role of clinical decision making in the process of diagnosis, and of the multiple factors that impact it, and b) a similar appreciation of the role of the healthcare system in supporting clinicians in their efforts to make accurate diagnoses. Although medicine has seen major gains in knowledge and technology over the last few decades, there is a consensus that the diagnostic failure rate remains in the order of 10-15%. This book provides an overview of the major issues in this area, in particular focusing on where the diagnostic process fails, and where improvements might be made.

Despite diagnosis being the key feature of a physician's clinical performance, this is the first book that deals specifically with the topic. In recent years, however, considerable interest has been shown in this area and significant developments have occurred in two main areas: a) an awareness and increasing understanding of the critical role of clinical decision making in the process of diagnosis, and of the multiple factors that impact it, and b) a similar appreciation of the role of the healthcare system in supporting clinicians in their efforts to make accurate diagnoses. Although medicine has seen major gains in knowledge and technology over the last few decades, there is a consensus that the diagnostic failure rate remains in the order of 10-15%. This book provides an overview of the major issues in this area, in particular focusing on where the diagnostic process fails, and where improvements might be made.

As a boy, Hardeep Singh Kohli knew where home was: Glasgow. But everyone else always assumed he was Indian. Because surely he couldn't be British, with his brown skin and turban? Thirty years later, Hardeep sets out on a journey to discover where he is really from. His story is as hilarious as it is moving.

This work offers a vivid journey into the medieval world of new religions and changing sensibilities. This story is an unforgettable tale about the cul de sacs of history, of pain and memory, of hope and hate.

This important volume provide a one-stop resource on the SAFER Guides along with the guides themselves and information on their use, development, and evaluation. The Safety Assurance Factors for EHR Resilience (SAFER) guides, developed by the editors of this book, identify recommended practices to optimize the safety and safe use of electronic health records (EHRs). These guides are designed to help organizations self-assess the safety and effectiveness of their EHR implementations, identify specific areas of vulnerability, and change their cultures and practices to mitigate risks. This book provides EHR designers, developers, implementers, users, and policymakers with the requisite historical context, clinical informatics knowledge, and real-world, practical guidance to enable them to utilize the SAFER Guides to proactively assess the safety and effectiveness of their electronic health records EHR implementations. The first five chapters are designed to provide readers with the conceptual knowledge required to understand why and how the guides were developed. The next nine chapters focus on the underlying informatics concepts, key research activities, and methods used to develop each of the guides. Each of these chapters concludes with a copy of the guide itself. The final chapter provides a vision for the future and the work required to ensure that future generations of EHRs are designed, developed, implemented, and used to improve the overall safety of the EHR-enabled healthcare system. Taken together, the information provided in this book should help any organization, whether large or small, implement its EHR program and improve the safety and effectiveness of its existing EHR-enabled healthcare systems. This volume will be extremely valuable to small, ambulatory physician practices and larger outpatient settings as well as for hospitals and professors and instructors charged with teaching safe and effective implementation and use of EHRs. It will also be highly useful for health information technology professionals responsible for maintaining a safe and effective EHR and for clinical and administrative staff working in EHR-enabled healthcare systems.

The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters.