This volume contains refereed manuscripts prepared from presentations made at the 27th annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT). The meeting was held in Hanover, NH, USA, at Dartmouth Medical School.

This book contains the refereed contributions from the 41st annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. Traditionally, ISOTT conferences are a place, where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The papers in this volume summarize some of the outstanding contributions from the 41st annual meeting. Special features in this volume include invited presentations from senior members of ISOTT for the theme "the wisdom of ISOTT" in which founders, past presidents and prize winners from previous meetings provided both cutting edge new knowledge and integrated overviews of critical aspects of the field. The presentations and manuscripts also include those provided by the special opportunity provided by having part of the ISOTT meeting overlap with the EPR-2013 meeting where both focused on preclinical and clinical measurements of oxygen, with a particular emphasis on cancer. Chapters 22, 24, 25 and 26 are open access under a CC BY 4.0 license via link.springer.com.

This volume contains refereed manuscripts prepared from presentations made at the 2ih annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT). The meeting was held in Hanover, NH, USA, at Dartmouth Medical School, the 3rd oldest medical school in the USA. ISOTT attempts to produce high quality pUblications on cutting edge topics relating to oxygen in living systerns. The goal is to allow contributors to contribute original data, as with a main-stream journal article, but also to voice individual opinions and ideas in a more relaxed scientific forum. The meeting brought together an international group of scientists who share a common interest in the measurement and role of oxygen in living systems. The organizers of ISOTT99 made a special effort to bring together people from industry, medicine, and basic sciences in order to improve the links in the chain of discovery through to application. As a result, this volume contains publications on a range of subjects. There are contributions from companies on modifiers of oxygen carrying capacity (allosteric modifiers of hemoglobin and infusible oxygen carriers or blood substitutes); technical reports on oxygen measurement devices including advances in near-infrared spectroscopy and imaging, oxygen electrodes, magnetic resonance spectroscopy and imaging, and fluorescence based measurements. There are medically related sections on modifying and measuring tumor oxygenation in order to improve therapy, assessment and interpretation of oxygenation in the central nervous system, and general issues relating oxygen to pathological conditions.