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Human Toxicology of Chemical Mixtures (Hardcover, 2nd edition): Harold Zeliger Human Toxicology of Chemical Mixtures (Hardcover, 2nd edition)
Harold Zeliger
R7,296 Discovery Miles 72 960 Ships in 12 - 17 working days

In this important reference work, Zeliger catalogs the known effects of chemical mixtures

on the human body and also proposes a framework for understanding and predicting their

actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The

author s focus is on illnesses that ensue following exposures to mixtures of chemicals

that cannot be attributed to any one component of the mixture.

In the first part the mechanisms of chemical absorption at a molecular and

macromolecular level are explained, as well as the body s methods of defending itself

against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed,

looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which

includes numerous case studies, examines specific effects of particular mixtures on

particular body systems and organs and presents a theoretical framework for predicting

what the effects of uncharacterized mixtures might be. Part IV covers regulatory

requirements and the need to adjust recommended exposure levels for products

containing mixtures. It also contains recommendations on how to limit exposure to

mixtures in the products we use and on how to limit release of mixtures into the

environment.

Providing brief summaries of each mixture and its effects, Zeliger provides a

comprehensive reference, a jumping off point for professionals (with extensive chapter

bibliographies) and an introduction to the topic for those studying traditional toxicology.

Addressing many inadequately understood illnesses and conditions such as asthma,

infertility and cancer, it will also be of interest to health professionals, environmental

scientists and lawyers.

Presents a theoretical framework for predicting the effects of chemical mixtures

for which no specific data exists (this predictive aspect is important due to the

vast number of different potential chemical combinations - far too many to

comprehensively catalog).

A quick and convenient source of hard to come by data on the rapidly developing

field of chemical mixtures, for groups including chemists and engineers,

toxicologists, health professionals and environmental scientists.

New and updated material comprises over 30% of this timely new edition, which

includes the latest research data alongside an expanded introduction to the science

and art of predicting the toxicological properties of chemical mixtures."

Oxidative Stress - Its Mechanisms and Impacts on Human Health and Disease Onset (Paperback): Harold Zeliger Oxidative Stress - Its Mechanisms and Impacts on Human Health and Disease Onset (Paperback)
Harold Zeliger
R3,287 R2,908 Discovery Miles 29 080 Save R379 (12%) Ships in 12 - 17 working days

Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation. Sections cover the causes and prevention of oxidative stress, the types of chemical exposures and environmental factors that precipitate disease, disease hallmarks and biomarkers, disease clusters, disease co-morbidities, free radical attacks at the cellular level, and the Oxidative Stress Index tool, its premise, and how it can be used to identify the primary causes of specific diseases and predict the likelihood of disease onset. With comprehensive coverage of not only the impact of OS due to chemical exposure but also the consequences of environmental factors, this book is a valuable resource for researchers and scientists in toxicology and environmental science, health practitioners, public health professionals, and others who wish to broaden their knowledge on this topic.

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