|
Showing 1 - 6 of
6 matches in All Departments
This book explores the author's wide-ranging work on muscle
research, which spans more than 50 years. It delves into the dogmas
of muscle contraction: how the models were constructed and what was
overlooked during the process, including their resulting
shortcomings. The text stimulates general readers' and researchers'
interest, highlights the author's pioneering work on the electron
microscopic recording of myosin head power and recovery strokes,
and presents a frank discussion on how the original work sometimes
tends to be overlooked by competing scientists, who hinder the
progress of science.
This book provides a comprehensive overview of the current progress
in muscle contraction and cell motility research. It discusses
structural, mechanical, and biochemical characteristics of
skeletal, cardiac, and smooth muscles, and cell motility. The
experimental objects of the studies described in this volume extend
from humans to molecules. A distinct feature of this volume is
that, in some chapters, evidence against the textbook view is
presented, showing how well-established dogma can be denied by an
unexpected discovery. This book is as interesting as it is
informative for general readers and young scientists alike, and it
is sure to inspire both to challenge the enticing mysteries that
still remain in this exciting research field.
This volume presents the proceedings of a muscle symposium, which
was supported by the grant from the Fujihara Foundation of Science
to be held as the Fourth Fujihara Seminar on October 28 -November
1, 2002, at Hakone, Japan. The Fujihara Seminar covers all fields
of natural science, while only one proposal is granted every year.
It is therefore a great honor for me to be able to organize this
meeting. Before this symposium, I have organized muscle symposia
five times, and published the proceedings: " Cross-bridge Mechanism
in Muscle Contraction (University of Tokyo Press, 1978),
"Contractile Mechanisms in Muscle" (plenum, 1984); "Molecular
Mechanisms of Muscle Contraction" (plenum, 1988); "Mechanism of
MyofIlament Sliding in Muscle contraction" (plenum, 1993);
"Mechanisms of Work Production and Work Absorption in Muscle"
(plenum, 1998). As with these proceedings, this volume contains
records of discussions made not only after each presentation but
also during the periods of General Discussion, in order that
general readers may properly evaluate each presentation and the
up-to-date situation of this research field. It was my great
pleasure to have Dr. Hugh Huxley, a principal discoverer of the
sliding fIlament mechanism in muscle contraction, in this meeting.
On my request, Dr. Huxley kindly gave a special lecture on his
monumental discovery of myofIlament-lattice structure by X-ray
diffraction of living skeletal muscle. I hope general readers to
learn how a breakthrough in a specific research field can be
achieved.
In contrast to common practice, we have always tried to include as
many discussions held at the meeting in our proceedings as
possible, so as to enable readers to properly evaluate each paper
presented, as well as to learn of future prospects in this field of
research. Although the policy of including discussions occasions a
long publication delay, we believe that it is worth repeating in
our future publication, as we have met a number of young
investigators fascinated by the discussions in our proceedings....
In the concluding remarks in this volume, Dr. Hugh E. Huxley, a
principal architect of the sliding filament mechanism of muscle
contraction, states that the molecular mechanism of myofilament
sliding remains mysterious to all of us. We hope that this volume
will stimulate muscle investigators to design and perform novel
experiments to clarify the mysteries in muscle contraction.' Haruo
Sugi and Gerald H. Pollack, excerpted from the Preface.
Sliding Filament Mechanism in Muscle Contraction Fifty Years of
Research covers the history of the sliding filament mechanism in
muscle contraction from its discovery in 1954 by H.E. Huxley
through and including modern day research. Chapters include topics
in dynamic X-ray diffraction, electron microscopy, muscle
mechanisms, in-vitro motility assay, cardiac versus smooth muscle,
motile systems, and much more.
|
You may like...
Hampstead
Diane Keaton, Brendan Gleeson, …
DVD
R66
Discovery Miles 660
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
|