Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of -crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina. A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.

Purdah, which can be formal law or informal custom, involves keeping women segregated from society, restricting their independence, and obliging them to dress in clothing that fully covers them. First published by Kegan Paul in 1932, this was a seminal book for the women's rights movement in general, and the Indian Woman's Movement in particular, and remains highly relevant today, as Indian, Islamic and Asian women continue to feel the conflict between modernity and tradition. Swiss by birth and married to an Indian, the author had a unique opportunity to see life in India from the perspective of women in purdah. Beginning in the Vedic period, she shows how the institution of purdah developed over time, describes purdah as long practiced in India, and then details the various reform and suffragette measures undertaken to eradicate it and the effect of the Nationalist movement on Indian women's freedom. There are clear parallels with women in other countries. In recent decades, purdah is once again reasserting itself in parts of India and elsewhere as conservative forces gain ground. This important work gives insight into the roots and strength of this tradition.

First published in 2006. Purdah, which can be formal law or informal custom, involves keeping women segregated from society, restricting their independence and regulating their dress. This classic work, published in 1032 was the first accurate description of the institution of Purdah, its effects on the women of India and their rising revolt against it. Written by a woman who herself lived the life pictured in the books, this was a seminal book for the women's rights movement and general and Indian's women's movement in particular.

Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of -crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina. A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.

The two-volume set LNCS 7649 + 7650 constitutes the refereed proceedings of the 11th International Semantic Web Conference, ISWC 2012, held in Boston, MA, USA, in November 2012. The International Semantic Web Conference is the premier forum for Semantic Web research, where cutting edge scientific results and technological innovations are presented, where problems and solutions are discussed, and where the future of this vision is being developed. It brings together specialists in fields such as artificial intelligence, databases, social networks, distributed computing, Web engineering, information systems, human-computer interaction, natural language processing, and the social sciences. Volume 1 contains a total of 41 papers which were presented in the research track. They were carefully reviewed and selected from 186 submissions. Volume 2 contains 17 papers from the in-use track which were accepted from 77 submissions. In addition, it presents 8 contributions to the evaluations and experiments track and 7 long papers and 8 short papers of the doctoral consortium.

The two-volume set LNCS 7649 + 7650 constitutes the refereed proceedings of the 11th International Semantic Web Conference, ISWC 2012, held in Boston, MA, USA, in November 2012. The International Semantic Web Conference is the premier forum for Semantic Web research, where cutting edge scientific results and technological innovations are presented, where problems and solutions are discussed, and where the future of this vision is being developed. It brings together specialists in fields such as artificial intelligence, databases, social networks, distributed computing, Web engineering, information systems, human-computer interaction, natural language processing, and the social sciences. Volume 1 contains a total of 41 papers which were presented in the research track. They were carefully reviewed and selected from 186 submissions. Volume 2 contains 17 papers from the in-use track which were accepted from 77 submissions. In addition, it presents 8 contributions to the evaluations and experiments track and 7 long papers and 8 short papers of the doctoral consortium.

This book constitutes the proceedings of the 12th International Conference on Web Information Systems Engineering, WISE 2011, held in Sydney, Australia, in October 2011.
The 17 revised full papers and 11 revised short papers presented together with 7 demo papers were carefully reviewed and selected from 96 submissions. The papers contained in these proceedings address challenging issues in software services, Web application engineering and modelling, Web search, social networks, Web semantics, and information retrieval and extraction.

This volume contains the papers from the technical programmeof the 5th Eu- pean Semantic Web Conference, ESWC 2008, that took place during June 1-5, 2008 in Tenerife, Islas Canarias, Spain. ESWC 2008 was the latest in a series of annual, international events foc- ing on the dissemination and discussion of the latest research and applications of Semantic Web technologies. The call for papers saw over 270 submissions, a comparable ?gure to the previous year, indicating that the conference series has reached a certain level of maturity. The review process was organized - ing a two-tiered system. First, each submission was reviewed by at least three members of the ProgrammeCommittee. Submissions were also assignedto a - niorProgrammeCommitteemember, wholed discussionsbetweenreviewersand provided a metareview and provisional decision. A physical Programme C- mittee meeting was then held, where the ?nal decisions weremade. Competition was as strong as ever, and the Programme Committee selected 51 papers to be presented at the conference. In addition to the technical research paper track, a system demo track was included, withits ownreviewprocess. Twenty-?vedemo paperswereselectedfor publication. System demo authors were given the opportunity to present their workin dedicated sessionsduring the conference, while anevening receptionwas also devoted to the presentation of posters and demonstrations of systems. As in past years, ESWC subscribed to the call to "eat our own dog food," withthepublicationofarichsetofsemanticmetadatadescribingtheconference. Three invited talks were given by distinguished scientists: Nigel Shadbolt (Garlik Ltd.

In diesem Werk zum Thema Software-Architekturen veranschaulichen drei international renommierte Experten den Zusammenhang zwischen Prinzipien, Standardarchitekturen und praxisrelevanten Problemstellungen aus den Bereichen Web Services, Peer-to-Peer, Workflow und weiteren Anwendungsgebieten. Dieses Buch richtet sich an Praktiker, Software-Projektmanager und Studenten der Informatik/Wirtschaftsinformatik, die fur Design und Entwicklung von grossen verteilten Softwaresystemen verantwortlich oder am Einsatz solcher Systeme in ihrem Arbeitsbereich interessiert sind. Hier wird erstmals der "State of the Art" in der Forschung industrierelevant und verstandlich umgesetzt. Die Autoren konnen auf jahrelange Erfahrung im Forschungs- und Entwicklungsbereich im Rahmen von grossen multinationalen Entwicklungsprojekten verweisen."

This book develops a conceptual framework for the relationship between organisation and output, and applies it to the analysis of German and British export support services. These findings help to explain why one organisation may be different from another, but equally effective and efficient, and why no panacea for effective and efficient organisation has been found. They also suggest angles from which existing organisations and blueprints of 'better' organisations can be examined.

In diesem Werk zum Thema Software-Architekturen veranschaulichen drei international renommierte Experten den Zusammenhang zwischen Prinzipien, Standardarchitekturen und praxisrelevanten Problemstellungen aus den Bereichen Web Services, Peer-to-Peer, Workflow und weiteren Anwendungsgebieten. Dieses Buch richtet sich an Praktiker, Software-Projektmanager und Studenten der Informatik/Wirtschaftsinformatik, die fur Design und Entwicklung von grossen verteilten Softwaresystemen verantwortlich oder am Einsatz solcher Systeme in ihrem Arbeitsbereich interessiert sind. Hier wird erstmals der "State of the Art" in der Forschung industrierelevant und verstandlich umgesetzt. Die Autoren konnen auf jahrelange Erfahrung im Forschungs- und Entwicklungsbereich im Rahmen von grossen multinationalen Entwicklungsprojekten verweisen."