This book, which is the first of a series devoted to the chemistry of pyrrole and its derivatives, presents the basic structural, physical and chemical properties of 1H-pyrrole and of the less prevalent 2H-and 3H-isomers, together with the synthesis of the three systems. Since its inital detection in coal, tar and bone oil by Runge in 1834, pyrrole has been an intriguing compound; one which, although being highly susceptible to oxidation and polymerization, occupies a key role in life. Such was its importance as the basic nitrogen heterocycle in porphins and chlorins that much of our early knowledge of the simple ring system revolved around the biologically more important derivatives.

The third part of Volume 32 deals with two major groups of quinoline compounds, the aldehydes and the ketones. The treatment differs from that adopted in previous parts, as the material is arranged entirely in the form of information on properties, but the chapters make no pretence of recording all information on the chemical and physical properties of quinoline aldehydes or ketones. Nevertheless, in common with Parts One and Two, all references to quinoline aldehydes and ketones are included as far as possible.

Introduction to the Pteridines.

Primary Syntheses from Pyrimidines.

Primary Syntheses from Pyrazines or Other Heterocycles.

Pteridine and Its Alkyl and Aryl Derivatives.

Halogenopteridines.

Tautomeric Pteridinones and Extranuclear Hydroxypteridines.

Aloxypteridines, N-alkylpteridines, and Pteridine N-oxides.

The Sulfur-containing Pteridines.

Pteridine Amines and Imines.

Pteridinecarboxylic Acids and Related Compounds.

The Hydropteridines.

Ionization and Spectra.

Table of Simple Pteridines.

References.

Index.

This volume attempts to cover important issues of the chemistry of one of the most central heterocycles. It focuses particularly on its physical properties, nucleophilic aromatic substitution and pharmacologically active compounds. The book is Part 4 of five parts which form a complete coverage of thiophene chemistry published since 1950.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

This book classifies methods of synthesizing a heterocyclic ring which is fused to another ring. Classification is based on the functional group or groups present in the substrate, each chapter being devoted to the reactions of a particular pair of groups. The groups are arranged alphabetically so that they can be found easily. The book enables the reader to locate references (over 2000 are included) to the conversion of a wide variety of functional groups into heterocyclic rings of five to eight atoms. Each cyclization is shown as an equation which contains concise details or reagents, conditions, and yields. Since the classification of each cyclization is based on the functional groups involved, locating the relevant reference is independent of the identity of the ring in the substrate. This simplifies the search for the relevant reference.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

The chemistry of heterocyclic compounds constitutes one of the broadest and most complex branches of chemistry. The diversity of synthetic methods utilized in this field, coupled with the immense physiological and industrial significance of heterocycles, combine to make the general heterocyclic arena of central importance to organic chemistry.

This is Part 1 of a projected sub-series on isoxazoles and is devoted to mono-nuclear isoxazoles and to their dihydro- and tetrahydro-derivatives. Each chapter represents a survey on physical properties, syntheses and reactions of the three classes of compounds. The book collects data and references up to the end of 1984 and readers can find a critical survey of the chemistry of monocyclic isoxazoles, isoxazolines and isoxazolidines, covering all relevant spectroscopic and other physical properties, including methods of preparation and all reactions of some importance. Special emphasis has been laid on the increasing popularity of isoxazoles as key intermediates in the synthesis of complex molecules.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

This volume describes in detail all of the important syntheses and reactions of oxazoles and oxazolones published through the first quarter of 1984. A section involving the use of oxazoles in synthesis will be of interest to most organic chemists. Of interest to heterocyclic and medicinal chemists is an extensive treatment of the synthesis of other heterocycles via oxazoles, oxazolones and mesoionic oxazoles. Extensive tables of oxazoles and oxazolones with literature references give easy access to the synthesis of these compounds. Most treatments of oxazole chemistry give only synthesis and reactions. This volume emphasizes the use of oxazoles as synthetic reagents as well as presenting the more classical treatments of oxazole chemistry. In additon, it contains the only extensive list of tables of oxazole derivatives. The book gives a list of spectroscopic properties of oxazoles, and offers the most detailed treatment of mesoionic oxazoles including syntheses, spectroscopy and reactions.