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The human cardiovascular and respiratory control systems represent
an important focal point for developing physiological control
theory because of the complexity of the control mechanisms
involved, the interaction between cardiovascular and respiratory
func--tion, and the importance of this interaction in many clinical
situations. This volume brings together the range of control
processes involved in the effective regulation of these systems and
develops modeling themes, strategies, and key clinical applications
using contemporary mathematical and control methodologies. The
reader will gain an appreciation of how analytical techniques and
ideas from optimal control theory, systems theory, and numerical
analysis can be utilized to better understand the regulation
processes in human cardiovascular and respiratory systems.
Cardiovascular and Respiratory Systems uses a principle-based
modeling approach and analysis of feedback control regulation to
elucidate the physiological relationships. Models are arranged
around specific questions or conditions, such as exercise or sleep
transition, and are generally based on physiological mechanisms
rather than on formal descriptions of input-output behavior. The
authors ask open questions relevant to medical and clinical
applications and clarify underlying themes of physiological control
organization. Current problems, key issues, developing trends, and
unresolved questions are highlighted.
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