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To date, there are many reports about the tumor progression and
local invasion of ameloblastoma as well as bone resorption induced
by the tumor cells. However, those studies have not described in
detailed the histological features of ameloblastoma in terms of
stroma and bone invasion. In this book therefore, discuss the
stromal type with their sub types. In ameloblastoma, stroma acts
not only in bone resorption but also causes suppression of new bone
formation. sFRP-2, a Wnt antagonist is the main factor for the
impaired bone formation. And activating RANKL with the help of TGF-
1 induced osteoclastogenesis. It causes bone destruction without a
proportional osteoblastic reaction, resulting in an uncoupling of
the normal bone remodeling sequence. So, the final volume of the
bone destruction was less with a large number of osteoblast.
Therapies targeting the inhibition of sFRP-2 and RANKL may
potentials be used in inhibiting ameloblastoma's growth as well as
other osteolytic disease.
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