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Many extrapyramidal motor diseases result from underlying
neurodegenerative processes, which however are very advanced at the
time the clinical diagnosis is made. From animal experiments it
seems likely that we may soon have several substances that provide
neuroprotective effects, but that their therapeutic use must be as
early as possible. This fact was the starting point for the
meeting, held at Chiemsee, that formed the basis of this book. The
idea was to develop in strumental methods that, first, permit an
earlier diagnosis by drawing on the experience of experts and,
second, provide a better resolution of successful therapy than the
currently used methods. As early as 1886, Charcot tried to
differentiate the tremor of polysclerosis and Parkinson patients by
using a drum developed by Marey, a physiologist. Subse quently,
many apparatuses were developed to better identify movement
disorders, initially for diagnostic purposes. Most of these methods
proved to be inferior to the skill of experienced observers. In the
last two decades, however, both the technical advances made in
measuring methods and the improvements achieved in methods of
evaluation have led to marked advances in the quantification of
motor dis turbances. An objective of the symposium held at Chiemsee
and of this book is to provide an overview of the procedures that
are currently commonly used for extrapyramidal movement disorders,
and to identify their potential and limitations."
Expert clinicians and basic scientists with a special interest in
Parkinson's disease review the current state of science and
clinical therapeutics of the disease. Therefore these articles
represent an authorative review of the current state of knowledge
regarding preclinical course and symptomatology, subtypes with
their impact on the pathology, genetic alterations, novel
mechanisms of neuronal cell death, diagnostic tools and old and
novel therapeutic approaches with respect to neuroprotection and
neuroregeneration in Parkinson's disease. Particular emphasis has
been placed on a novel antiparkinsonian drug called budipine with
various modes of action also influencing altered non dopaminergic
systems in Parkinson's disease. It is evident, that many questions
on the cause, course and treatment of Parkinson's disease are still
unanswered and therefore the ideal way to treat a parkinsonian
patient remains to be defined.
Expert clinicians and basic scientists with a special interest in
Parkinson's disease review the current state of science and
clinical therapeutics of the disease. Therefore these articles
represent an authorative review of the current state of knowledge
regarding preclinical course and symptomatology, subtypes with
their impact on the pathology, genetic alterations, novel
mechanisms of neuronal cell death, diagnostic tools and old and
novel therapeutic approaches with respect to neuroprotection and
neuroregeneration in Parkinson's disease. Particular emphasis has
been placed on a novel antiparkinsonian drug called budipine with
various modes of action also influencing altered non dopaminergic
systems in Parkinson's disease. It is evident, that many questions
on the cause, course and treatment of Parkinson's disease are still
unanswered and therefore the ideal way to treat a parkinsonian
patient remains to be defined.
At the time when "Parkinson's Disease" is diagnosed in a patient,
roughly two thirds of dopaminergic neurons of substantia nigra are
already degenerated. The onset of the disease must, therefore, be
much earlier. This book deals with early diagnosis and early
preventive treatment which may sustain the process underlying the
disease. By use of psychometric, kinesiologic, physiologic,
histologic, biochemical, endocrinologic, pharmacologic and imaging
techniques, including positron-emission tomography and brain
mapping, specialists tried to focus on new diagnostic criteria. New
methods including psychometric evaluation, apparative measurement
of movement, analysis of peripheral blood and urinary constituents
have supplemented this approach. It has been agreed that early
preventive therapy consists of low dosis of L-DOPA plus
benserazide, L-deprenyl and dopaminergic agonists.
Internationales Parkinson-Symposium, Berlin, 23. bis 25. Januar
1987
Die Vielfalt der hier vorgestellten Beitrage spiegelt das
unermudliche Bestreben aller in die Therapie von Parkinsonpatienten
Involvierten wider, Lebensqualitat und Wohlbefinden von chronisch
Kranken und deren Angehoerigen zu verbessern und diese komplexe
Erkrankung auch vor dem Hintergrund von Begleiterkrankungen zu
betrachten. Einerseits wird die Bedeutung vegetativer und
sensorischer Stoerungen diskutiert, andererseits wird der Einfluss
von Begleiterkrankungen und ausgepragten Begleitsyndromen auf
Therapie und Verlauf der Erkrankung vor dem Hintergrund
persoenlicher Erfahrungen vorgestellt. Diese Zusammenstellung
bietet Erkenntnisse uber moegliche Interaktionen, die im Rahmen der
medikamentoesen Kombinationstherapie zu beachten sind, sowie eine
Bewertung der gangigen intensivmedizinischen Vorgehensweisen und
der neu entwickelten Therapieverfahren wie der
Tiefenhirnstimulation und eine Bewertung von Langzeitaspekten.
Die Vielfalt der angewandten Methoden in der nichtmedikamentoesen
adjuvanten Therapie spiegelt das Bestreben in den Parkinsonkliniken
mit rehabilitativem Charakter wider, Lebensqualitat und
Wohlbefinden chronisch Kranker und deren Angehoeriger zu
verbessern. Die auf einem Treffen der deutschen Parkinsonkliniken
vorgestellten Therapien zeigen, dass bei Parkinsonpatienten neue
Lebensinhalte gegeben und neue Interessen geweckt werden koennen.
Mit zunehmender Spezialisierung von Psychiatrie und Neurologie und
der dadurch bedingten Auflosung des einheitlichen Faches
Nervenheilkunde werden die Grenzbereiche zwischen beiden Fachern
ein diagnostisches und therapeutisches Problem. Dieser Band enthalt
Beitrage sowie die wichtigsten Diskussionsbemerkungen der zweiten
"Begegnungs-Tagung" zwischen Psychiatern und Neurologen.
Thematische Schwerpunkte sind Gen-Diagnostik, Diagnose,
Differentialdiagnose und Therapie der Demenz, organische
Depressionen und ihre Differentialdiagnose,
Plasmaspiegelbestimmungen von Pharmaka in der Neurologie und
Psychiatrie sowie Pradiktion des Therapieerfolges bei
neurologischen und psychiatrischen Erkrankungen.
Das Buch besch{ftigt sich mit Grenzgebieten zwischen Psychiatrie
und Neurologie. Es geht um diagnostische und therapeutische Fragen,
die in der allt{glichen Versorgungssituation immer wieder
auftauchen und die f}r eine kompetente Antwort nur im
interdisziplin{ren Gespr{ch zwischen Psychiatern und Neurologen
gefunden werden kann. Das Buch enth{lt die Referate und die
Diskussionen einer Tagung, an der namhafte deutsche Neurologen und
Psychiater aus verschiedenen Universit{tskliniken teilgenommen
haben. Thematische Schwerpunkte waren dyskinetische St-rungen,
katatone St-rungen, K-rpergef}hlsst-rungen, Krampfanf{lle,
therapeutische Risiken von Psychopharmaka.
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