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Preeclampsia is a form of high blood pressure manifested during
pregnancy, it is a common major complication causing significant
morbidity and mortality; however, its etiology is unknown. The
systemic vasculature is a target tissue for sex steroid hormones.
Estrogen, androgen, and progesterone all influence the function and
pathophysiology of the systemic circulation by influencing
endothelial derived nitric-oxide pathway. Evidence suggests that
sex steroids also modulate electrolyte homeostasis, but data on
cation pattern during pregnancy are conflicting. Moreover, the
status of ionized calcium and magnesium during pregnancy and its
complication preeclampsia, and its relation with endothelial
derived nitric-oxide and sex hormones have not been described
adequately. The aim of this study is to demonstrate the pattern of
sex steroids, minerals and electrolytes during preeclampsia with
respect to normal pregnancy, and the correlation of the above
parameters with nitric-oxide pathway. This study shows
thatpreeclamptics (in different gestational age groups) experience
vasospasm, hyperandrogenemia, altered electrolytes and mineral
status, with no difference in sex steroids.
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