"For the blood is the life . . . . "(Deut. 12 :23) " . . . because the blood, in its value as life, makes atonement" (Lev. 17: 11) HemoPhilia is a rare disease, severe hemophilia rarer still, yet the written history of hemophilia extends back over a millennium and a half. In the ancient Middle East, blood and life were coupled. Blood was the primary substance necessary for life, given to God in sacrifice and forbidden as a food to mortals by Levitical law. Blood was essential for rites of purification and consecration. But the flow of blood during menstruation or parturition rendered a woman unclean. The circumcision of a male child required 33 days of "blood purification" by the mother. ' Circumcision, the visible reminder of the covenant of Abraham lijith Yahweh, was required of newborn Jewish males. It "connote(d) suitability for participation in what God is doing. "2 Hence, free and uncontrolled bleeding of the male child during circumcision, during the ratification of God's covenant, would be noted with awe and concern by those of the Jewish faith. It should not be surprising that the first genetic counseling offered to families with hemophilia is found in the Babylonian Talmud (compilation of Jewish law dated to about the third century AD) and concerns the necessity for circumcision in families with what we would now call hemophilia.

Principles of Rubin’s Pathology, Seventh Edition distills the renowned coverage of Rubin’s Pathology, Seventh Edition into a focused, approachable guide to the essentials of pathology. This resource introduces principles and mechanisms of pathology, followed by organ-specific information, extracting key information on pathogenesis, epidemiology, and clinical features of diseases. Detailed images clarify challenging content, and companion online resources enable students to learn on the go and confidently prepare for exams. This edition is optimized for students seeking only the most critical information, making it an ideal resource for international medical schools, PA, pharmacy, nursing, and allied health programs. Streamlined content emphasizes essential concepts, including the use of bold terms and bulleted lists to emphasize key points, for the most efficient study of pathology available. Illustrations, photomicrographs, and clinical photographs clarify challenging content and represent the pathogeneses of disease. Highlighted boxes and helpful graphic icons identify Pathogenesis, Pathology, Epidemiology, and Clinical Features sections. Globally sourced content reflects an international spectrum of current practices and approaches. Online resources including new slide-based histopathology lectures presented by Dr. Rubin, original animations, and fully searchable text make learning more engaging and efficient. eBook available for purchase. Fast, smart, and convenient, today’s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more