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In multicellular organisms, communication between cells involves
secretion of proteins that bind to receptors on neighboring cells.
While this has been well documented, another mode of intercellular
communication has recently become the subject of increasing
interest: the release of exosomes. In cancer, tumor exosomes are
involved in various aspects of pathogenesis, including
proliferation, immunosuppression, and metastasis. Given the ability
of exosomes to export unneeded endogenous molecules from cells,
these structures hold great potential as anticancer therapeutic
agents. They are also being studied as prognostic markers for
cancer.
In multicellular organisms, communication between cells involves
secretion of proteins that bind to receptors on neighboring cells.
While this has been well documented, another mode of intercellular
communication has recently become the subject of increasing
interest: the release of exosomes. In cancer, tumor exosomes are
involved in various aspects of pathogenesis, including
proliferation, immunosuppression, and metastasis. Given the ability
of exosomes to export unneeded endogenous molecules from cells,
these structures hold great potential as anticancer therapeutic
agents. They are also being studied as prognostic markers for
cancer.
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