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The impressive advances in all branches of medical science during
the first half of this century with the discovery of many
chemotherapeutic or immunogenic agents gave rise to brilliant
achievements in the struggle against some infectious diseases and
aroused in many scientists the wishful thought that drugs for
cancer therapy would, soon lead to additional great success.
Notwithstanding ever-increasing worldwide endeavors, the major
problems in prevention or treatment of neoplastic diseases are
still unsolved. The approach to the resolution of these problems
follows many different pathways. Basic research tries to cast light
on the genetic and biochemical processes underly ing cell division
and differentiation as well as the interactions occurring between
the cell and the oncogenic stimulus, or between the neoplastic
cells and the different body systems endowed with immunological
reactivity. Another line of approach, coherent with the classic
basis of chemotherapy, relies upon the search for new compounds
selectively blocking the multiplication of the neoplastic cells.
The remarkable progress made in treating human cancer, as a result
of these efforts, has been until now ascribable chiefly to the
accomplishment of the chemo therapeutic approach. Studies on the
cytostatic activity of the anthracycline antibiotics carried out
over many years eventually led the investigators of Farmitalia
(Milan, Italy) to discover and characterize some new compounds
endowed with interesting chemotherapeutic properties against
malignant neoplastic diseases."
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