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The methods of molecular biology, biochemistry, immunocytochem
istry, and in-situ hybridization introduce new opportunities for
the classification and functional characterization of cell
receptors under normal conditions and for a better understanding of
pathogenetic mechanisms in human diseases. The cellular
localization and trans location of receptor proteins can be
identified using morphological methods, and it is apparent that
receptors and receptor defects play an important role in pathology,
notably in genetic diseases, endocrine disorders, atherosclerosis,
infections, and cancer. In this volume in ternational experts give
a current review of the morphology and pathological aspects of cell
receptors. The complex communication of multicellular organisms is
coordi nated by two regulatory systems: neural and humoral. Both
systems function via signaling substances (ligands) and
signal-recognizing and -transmitting molecules, called receptors.
The historical develop ment of the receptor concept is based upon
Paul Ehrlich's theory of "receptors in the immune system,"
Langley's "receptive substances in postssynaptic membranes," and
Earl Sutherland's discovery of "sec ond messengers" (cAMP and
Ca2])."
When presented with the task of editing a volume on such a wide
When presented with the task of editing a volume on such a wide and
and diverse diverse topic topic as as Ovarian Ovarian Pathology,
Pathology, it it is is difficult difficult to to know know how how
to to limit limit the the range range of of subjects subjects to to
be be covered covered when when there there are are so so many many
taxonomical taxonomical entities, entities, both both neoplastic
neoplastic and and reactive reactive that that could could be be
included. included. However, However, I I have have chosen chosen
to to cover cover concepts concepts that that are are not not
usually usually dealt dealt with with in in depth depth in in
Gynaecological Gynaecological Pathology Pathology textbooks.
textbooks. From From the the clinicopathological
clinicopathological viewpoint, viewpoint, a a wealth wealth of of
new new data data has has been been updated updated and and
critically critically reappraised. reappraised.
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