This volume begins with a summary of the classical genetic studies and molecular genetic studies of the most common diseases, and indicates what makes them amenable to analysis and treatment. A range of possible future therapeutic options are discussed, from conventional drug targets through to gene therapy. The final chapters assess the value of diagnosis and prediction of the inheritance of various diseases.

A WAKE-UP CALL TO FACE THE FACTS This books breaks the mould of traditional coaching approaches to challenge coaches and their clients to achieve courageous goals that sustainably transform bottom line performance. Based on the authors' extensive experience working with international Board level teams, it suggests that for too long coaches have shied away from adopting a more challenging stance in their work - a stance that can provoke greater performance and unlock deeper potential in business leaders and their teams. In particular, the authors offer a new coaching approach, FACTS, to help coaches develop this challenging stance. The FACTS approach with its emphasis on Feedback, Accountability, Courageous Goals, Tension and Systems Thinking is explored in theory and in practice using case studies, example dialogues and practical exercises. Long held coaching principles such as being non-directive, building rapport and holding to the client's agenda are put under the spotlight with the authors questioning their relevance to a 21st century business environment where the needs of the wider business must take precedence over the me me me of any specific executive. This is a timely wake up call for anyone who is responsible for the performance of others - be they coach, business leader or leadership development expert. An original and thought-provoking message that dares the reader to face the FACTS, and accept the coaching challenge.

The 'Advanced Methods' series is intended for advanced undergraduates, postgraduates and established research scientists. Titles in the series are designed to cover current important areas of research in life sciences, and include both theoretical background and detailed protocols. The aim is to give researchers sufficient theory, supported by references, to take the given protocols and adapt them to their particular experimental systems.
Microarrays and Microplates title looks at the new microarray and microplate-based technologies which facilitate large-scale analysis of DNA sequence variants, mRNA molecules and proteins. The book provides a review of the various methodologies being used to identify genetic variants and gene regulation and guides readers through both the application of these methodologies and experimental procedures.