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Antibiotics are secondary metabolites produced by microorganisms,
extremely important to the health of our society. Cephalosporins
are broad-spectrum antibiotics which are very similar in structure
and action to penicillins but more resistant to - lactamases.
Optimization of media is useful to increase the production of
antibiotics. Induction of mutation is commonly employed to increase
the yield of secondary metabolites like antibiotics. Chemical
mutation is preferred method because of the ease in handling and
avoiding the hazardous effects of radiations. Usually, mutations
are induced in those microorganisms, which are well-known and well
adapted for the production of that particular product. Selected
microbes are cultured and treated with chemicals. The mutants are
then screened for the particular product. There is an evidence of
increasing production of secondary metabolites. The HPLC methods
used in biotechnology are compared with other used for on-line
analysis of -lactams in biotechnology. The data based on HPLC
analysis is much reliable.
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