The updated and expanded second edition of this book presents a contemporary review of the basic science, engineering technology, and clinical practice of cardiac bioelectric therapy. It covers the rapidly expanding technological development of pacemakers and defibrillators as well as ablative therapy, electrophysiological mapping, and other clinical diagnostic and therapeutic breakthroughs. The book highlights many different aspects of bioelectric therapy, including history, biophysical and computational concepts, basic electrophysiology studies, engineering technology advances, and clinical perspectives. In this revised edition, leading clinical and basic electrophysiologists share their perspectives on the science behind the mechanisms of cardiac arrhythmias; breakthrough technologies for scientific and clinical investigation of heart rhythm disorders; theoretical conceptualization of arrhythmias and treatment using state-of-the-art computational approaches; and novel approaches to treatment of cardiac arrhythmias using implantable devices, percutaneous ablation therapies, machine learning, and other approaches. The Second Edition of Cardiac Bioelectric Therapy is an essential resource for physicians, residents, fellows, and graduate students in clinical cardiac electrophysiology, cardiology, and cardiac surgery as well as researchers, professionals, and students in biomedical, mechanical, and electrical engineering.

Pacing and defibrillation have become the leading therapeutic treatments of heart rhythm disorders, including bradycardia and tachycardia. The success of these therapies is largely due to centuries of scientific inquiry into the fundamental mechanisms of bioelectric phenomena in the heart. History of successful development of bioelectric therapies includes development of experimental and theoretical methodologies, novel bioengineering approaches, and state-of-the-art clinical implantable device therapies. The purpose of this book is to present a uniform thematic collection of reviews written by the leading basic and applied scientists working in basic bioengineering research laboratories, who have contributed to the development of current understanding of the fundamental mechanisms of pacing and electrophysiology, and who are at the leading edge of further developments in electrotherapy. The book will start from the historic overview of the subject, including the development of the pacemaker and defibrillator, evolution of theories of cardiac arrhythmias and experimental methods used in the field over the centuries. Leading experts in the field will write these chapters. The second part of the book will focus on rigorous treatment of the fundamental theory of interaction between electric field and cardiac cell, tissue, and organ. Chapters will be written by top notch scientists, who made critically important contributions to the development of these theories. Part 3 will provide summary of several decades of research involving electrode recordings and multielectrode mapping of ventricular fibrillation and defibrillation in humans and animal models of arrhythmias. Part 4 will present new insights into defibrillation gained due to the advent of optical imaging technology, which permitted to map defibrillation without overwhelming shock-induced artifacts present in electrode recordings. Part 5 will provide rigorous overview of the methodologies, which made research of physiological and engineering aspects of electrotherapy possible. And finally, part 6 will present possible future of implantable devices and electrotherapy in the treatment of cardiac rhythm disorders.