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The Ghrelin receptor was identified before its natural ligand
ghrelin. This receptor is found both centrally and peripherally,
and has been shown to affect various processes, such as food
intake, gut motility, memory, glucose and lipid metabolism,
cardiovascular performances, reproduction, memory, and
immunological responses, amongst others. The functions of the
ghrelin receptor in the central nervous system are numerous and are
still being explored. In this book we specifically focus on the
various roles of the ghrelin receptor in the central nervous
system. In a first set of chapters, the book will focus on the
discovery and the properties of this intriguing constitutively
active G-protein coupled receptor, on its multiple intracellular
transduction mechanisms and the various subtypes of the currently
known ghrelin receptor complexes. Next, the book will elaborate on
the mitochondrial mechanisms regulated by the ghrelin receptor, its
role in feeding and drug addictive mechanisms, memory, sleep and
arousal. The final chapters focus on the potential of this receptor
as a target for the treatment of neurological disorders including
Parkinson's disease, epilepsy, anxiety and depression.
The Ghrelin receptor was identified before its natural ligand
ghrelin. This receptor is found both centrally and peripherally,
and has been shown to affect various processes, such as food
intake, gut motility, memory, glucose and lipid metabolism,
cardiovascular performances, reproduction, memory, and
immunological responses, amongst others. The functions of the
ghrelin receptor in the central nervous system are numerous and are
still being explored. In this book we specifically focus on the
various roles of the ghrelin receptor in the central nervous
system. In a first set of chapters, the book will focus on the
discovery and the properties of this intriguing constitutively
active G-protein coupled receptor, on its multiple intracellular
transduction mechanisms and the various subtypes of the currently
known ghrelin receptor complexes. Next, the book will elaborate on
the mitochondrial mechanisms regulated by the ghrelin receptor, its
role in feeding and drug addictive mechanisms, memory, sleep and
arousal. The final chapters focus on the potential of this receptor
as a target for the treatment of neurological disorders including
Parkinson's disease, epilepsy, anxiety and depression.
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