This book constitutes the refereed proceedings of the 10th Metadata and Semantics Research Conference, MTSR 2016, held in Goettingen, Germany, in November 2016. The 26 full papers and 6 short papers presented were carefully reviewed and selected from 67 submissions. The papers are organized in several sessions and tracks: Digital Libraries, Information Retrieval, Linked and Social Data, Metadata and Semantics for Open Repositories, Research Information Systems and Data Infrastructures, Metadata and Semantics for Agriculture, Food and Environment, Metadata and Semantics for Cultural Collections and Applications, European and National Projects.