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How Synthetic Drugs Work: Insights into Molecular Pharmacology of
Classic and New Pharmaceuticals provides comprehensive, structured
access to robust information on molecular pharmacology for
clinicians, research scientists and advanced health care students.
The book covers the foundations of molecular pharmacology and the
main drug classes, including detailed information on their
mechanisms of action and the application of molecular pharmacology
in drug development. This book is an ideal reference for graduate
students and researchers in pharmacology, however, researchers in
corporate settings will also benefit from the book's structured and
detailed coverage of mechanisms of action of synthetic drugs.
Mulberry, Morus alba L., as a non-toxic natural therapeutic agent,
belongs to the family of Moraceae, and has been cultivated in many
Asian countries such as China, India, Korea, Japan and Thailand
where the leaves were used as food for silkworms. It is a natural
food additive having carbohydrates, lipids, proteins, fibres,
sugars, vitamins, mineral etc. in appropriate proportion. It is a
potent food antioxidant commonly used as a dietary supplement.
Researchers suggested that it can be used as a good pharmaceutical
food. It has been used since ancient times in folk medicine for its
many medicinal properties. The plant has been used in Indian
tradition as a nervine tonic. This widely grown plant has been in
use by tribals of this country for ailments such as asthma, cough,
bronchitis, edema, insomnia, wound healing, diabetes, influenza,
eye infections and nose bleeds. The plant extract has been
demonstrated to posses free radical scavenging activity. It has
been extensively studied for its antidiabetic, antibacterial,
antianaphylactic, neuroprotective, hypolipidemic, hypotensive,
antiatherosclerotic, anticancer, antidepressant effects.
Lantana camara L. is regarded both as a notorious weed and a
popular ornamental garden plant and posseses various uses in folk
medicine in many parts of the world. The phytochemical
investigation of the methanolic extract of leaves resulted in
isolation terpenoidal glycosides namely urosolic acid glycosidic
oleiate (NEW), ursolic acid glycosidic stearate (NEW) and oleanolic
acid glucoside. Some esters like undecanyl Oleioate, dodecanyl
oleioate and carboxylic acids like ursolic acid and oleanolic acid
were successfully isolated. HPTLC fingerprint of the methanolic
extracts of L. camara leaves were performed. The solvent systems
were chloroform: methanol (99:1). Antidiabetic activities of the
Lantana camara were performed on streptozotocin induced diabetic
rats and the aqueous extracts of both the drugs showed significant
reduction in blood glucose level.
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