This book constitutes the refereed proceedings of the International Symposium on Bioinformatics Research and Applications, ISBRA 2012, held in Dallas, Texas, USA, in May 2012. The 26 revised full papers presented together with five invited talks were carefully reviewed and selected from 66 submissions. The papers address issues on various aspects of bioinformatics and computational biology and their applications.

The5th editionof the InternationalSymposium onBioinformaticsResearchand Applications (ISBRA 2009) was held during May 13-16, 2009 at Nova Sou- eastern University in Ft. Lauderdale, Florida. The symposium provides a forum for the exchange of ideas and results among researchers, developers, and prac- tioners working on all aspects of bioinformatics and computational biology and their applications. The technical program of the symposium included 26 contributed papers, selected by the Program Committee from a number of 55 full submissions - ceived in response to the call for papers. The technical program also included contributed papers and abstracts submitted to the Second Workshop on C- putational Issues in Genetic Epidemiology (CIGE 2009), which was held in c- junction with ISBRA 2009. Additionally, the symposium included poster s- sions and featured invited keynote talks by four distinguished speakers: Mikhail Gelfand from the Russian Academy of Sciences and Moscow State University spoke on evolution of regulatory systems in bacteria, Nicholas Tsinoremas from the Miller School of Medicine and the College of Arts and Sciences at the U- versity of Miami spoke on bioinformatics challenges in translational research, Esko Ukkonen from the University of Helsinki spoke on motif construction from high-throughputSELEXdata, andShamil SunyaevfromBrighamand Women's Hospital and Harvard Medical School spoke on interpreting population seque- ing data. We would like to thank the Program Committee members and external - viewers for volunteering their time to review and discuss symposium papers.

th The 4 edition of the InternationalSymposium on BioinformaticsResearchand Applications (ISBRA 2008) was held on May 6-9, 2008 at Georgia State U- versity in Atlanta, Georgia. The symposium provides a forum for the exchange of ideas and results among researchers, developers, and practitioners working on all aspects of bioinformatics and computational biology and their applications. The technical program of the symposium included 35 contributed papers, selected by the Program Committee from a number of 94 full submissions - ceived in response to the call for papers. The technical program also included six papers contributed to the First International Workshop on Optimal Data Mining in Gene Expression Analysis (ODGEA 2008), which was held in c- junction with ISBRA 2008. In addition to the contributed papers, the sym- sium included tutorials and poster sessions and featured invited keynote talks by six distinguished speakers. Andrew Scott Allen from Duke University and Dan Nicolae from the University of Chicago spoke on novel analysis methods for genome-wide association studies; Kenneth Buetow, director of the National Cancer Institute Center for Bioinformatics, spoke on the cancer Biomedical - formatics Grid; Andrey Gorin from Oak Ridge National Laboratory spoke on peptide identi?cation from mass spectrometry data; Yury Khudyakov from the Center for Disease Control and Prevention spoke on integrative viral molecular epidemiology; and Kwok Tsui from Georgia Institute of Technology spoke on data mining and statistical methods for analyzing microarray experiment

This book constitutes the refereed proceedings of the Third International Symposium on Bioinformatics Research and Applications, ISBRA 2007, held in Atlanta, GA, USA in May 2007.

The 55 revised full papers presented together with 3 invited talks were carefully reviewed and selected from a total of 146 submissions. The papers cover a wide range of topics, including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.

This book constitutes revised selected papers from the refereed proceedings of the 11th International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2021, held as a virtual event during December 16-18, 2021. The 13 full papers included in this book were carefully reviewed and selected from 17 submissions. They were organized in topical sections as follows: Computational advances in bio and medical sciences; and computational advances in molecular epidemiology.

This book constitutes the proceedings of the 10th International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2020, held in December 2020. Due to COVID-19 pandemic the conference was held virtually.The 6 regular and 5 invited papers presented in this book were carefully reviewed and selected from 16 submissions. The use of high throughput technologies is fundamentally changing the life sciences and leading to the collection of large amounts of biological and medical data. The papers show how the use of this data can help expand our knowledge of fundamental biological processes and improve human health - using novel computational models and advanced analysis algorithms.

This book constitutes the proceedings of the 16th International Symposium on Bioinformatics Research and Applications, ISBRA 2020, held in Moscow, Russia, in December 2020. The 23 full papers and 18 short papers presented in this book were carefully reviewed and selected from 131 submissions. They were organized in topical sections named: genome analysis; systems biology; computational proteomics; machine and deep learning; and data analysis and methodology.

This book constitutes revised selected papers from the 9th International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2019, held in Miami, Florida, USA in November 2019.The 15 papers presented in this volume were carefully reviewed and selected from 30 submissions. They deal with topics such as computational biology; biomedical image analysis; biological networks; cancer genomics; gene enrichment analysis; functional genomics; interaction networks; protein structure prediction; dynamic programming; and microbiome analysis.

This book constitutes the refereed proceedings of the 11th International Symposium on Bioinformatics Research and Applications, ISBRA 2015, held in Norfolk, VA, USA, in June 2015. The 34 revised full papers and 14 two-page papers included in this volume were carefully reviewed and selected from 98 submissions. The papers cover a wide range of topics in bioinformatics and computational biology and their applications.