Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

It is by no coincidence that another collaborative project is spear-headed by K2LD. Following the success of the Lien Villa Collective at Holland Park, Singapore in 2009, Ko Shiou Hee was asked to look at a similar concept for the Dalvey Estate property and to select and lead a group of architects in the making of a unique architecture expression and yet functional outcome, suitable for contemporary living and fit for rental. It was learning from Game Theory that Ko Shiou Hee succeeded in persuading his clients to adopt this sharing strategy both in the Lien Collective and the Dalvey 7 group. The selected architects must all adhere to the rules of the game and work on the same fees and briefs. All have to consider each other's placements and planning to maximise the benefit for all parties as a whole and eventually benefit the client. As architects, each firm, and their practicing architects, has been educated to work with social, economic, and environmental sensitivity. The world that architects operate in is driven by developers and stakeholders who maximise their gain through development strategies, but leave little chance to be true to the architectural profession. It is perhaps even more pressing for architects to address this issue of true collaborative spirit in this increasingly distortive egocentric world. Through this Dalvey 7 project, there is hope in the idea outlined in Game Theory to perpetuate and flourish in this profession to encourage sharing and collaboration. Perhaps more form of joint venture in various scales like big firm-small firm, local firm-foreign firm, developer-architect venture, design-built etc, will begin to surface.