|
Showing 1 - 6 of
6 matches in All Departments
This volume explores the myriad of techniques and methodological
approaches that are being used in breast cancer research. The
authors critically evaluate of the advantages and disadvantages of
current methodologies, starting with the tools available for
understanding the architecture of the human breast, including its
tissue and cellular composition. The volume discusses the
importance of functional studies in breast cancer research,
especially with the help of laser capture microdissection, which
allows the separation of small amounts of tissue, as well as
specific cells, for biochemical analysis. In addition, the authors
address methodologies including stem cell separation, which has
helped in significantly understanding their role in normal breast
development, but also further the understanding of breast cancer
and its therapeutic management. The use of in vitro techniques and
established cell lines for mechanistic studies in chemotherapeutic
approaches have been invaluable will be discussed. Imaging
techniques for evaluating in vitro and in vivo behavior of normal
and cancerous breast tissue will be explored, as it provides a
better understanding of the physiopathology of cancer. The volume
will also discuss the molecular analysis of gene function in breast
cancer through the transcriptomic and epigenomic profile. More
importantly, the advancement of more refined techniques in
sequencing will be covered. This monograph will be a comprehensive,
authoritative and timely, as it addresses the emerging approaches
used in breast cancer research.
This book will provide the latest advances in molecular and
cellular biology for establishing the foundation of a complete
understanding of the mechanisms of breast differentiation leading
to cancer prevention. The authors are based on the epidemiological
evidence indicating that early first full term pregnancy is a
protective factor in human against breast cancer and they have used
this paradigm and developed experimental systems in both in vivo
and in vitro that have demonstrated mechanistically how the
differentiation at the organ and cellular level takes place. This
knowledge has provided the blueprint for developing better
understanding of the basis of cancer prevention. The transcriptoma
analysis of the breast of pre and post-menopausal women has
established a genomic signature imprinted in the breast that
differs according to the reproductive history of the woman showing
that early first full term pregnancy reprogram the organ. This
reprogramming takes place at the chromatin level by changing the
transcriptional process. The modification of the transcriptional
control is due to the expression of non coding RNA sequences and
posttranscriptional control driven by the splicesome. The
plasticity of the genome of the human breast make possible this
reprogramming that is not only induced by the physiological process
of pregnancy but by the use of hormones that mimic pregnancy
without pregnancy. The author have established the basis of
clinical trials for prevention and the discovery that short 15aa
peptides of the chorionic gonadotropin hormone can be used in human
breast cancer prevention based on preclinical and clinical data.
This volume explores the myriad of techniques and methodological
approaches that are being used in breast cancer research. The
authors critically evaluate of the advantages and disadvantages of
current methodologies, starting with the tools available for
understanding the architecture of the human breast, including its
tissue and cellular composition. The volume discusses the
importance of functional studies in breast cancer research,
especially with the help of laser capture microdissection, which
allows the separation of small amounts of tissue, as well as
specific cells, for biochemical analysis. In addition, the authors
address methodologies including stem cell separation, which has
helped in significantly understanding their role in normal breast
development, but also further the understanding of breast cancer
and its therapeutic management. The use of in vitro techniques and
established cell lines for mechanistic studies in chemotherapeutic
approaches have been invaluable will be discussed. Imaging
techniques for evaluating in vitro and in vivo behavior of normal
and cancerous breast tissue will be explored, as it provides a
better understanding of the physiopathology of cancer. The volume
will also discuss the molecular analysis of gene function in breast
cancer through the transcriptomic and epigenomic profile. More
importantly, the advancement of more refined techniques in
sequencing will be covered. This monograph will be a comprehensive,
authoritative and timely, as it addresses the emerging approaches
used in breast cancer research.
The book will provide an exhaustive and clear explanation of how
Statistics, Mathematics and Informatics have been used in cancer
research, and seeks to help cancer researchers in achieving their
objectives. To do so, state-of-the-art Biostatistics,
Biomathematics and Bioinformatics methods will be described and
discussed in detail through illustrative and capital examples taken
from cancer research work already published. The book will provide
a guide for cancer researchers in using Statistics, Mathematics and
Informatics, clarifying the contribution of these logical sciences
to the study of cancer, thoroughly explaining their procedures and
methods, and providing criteria to their appropriate use.
This book will provide the latest advances in molecular and
cellular biology for establishing the foundation of a complete
understanding of the mechanisms of breast differentiation leading
to cancer prevention. The authors are based on the epidemiological
evidence indicating that early first full term pregnancy is a
protective factor in human against breast cancer and they have used
this paradigm and developed experimental systems in both in vivo
and in vitro that have demonstrated mechanistically how the
differentiation at the organ and cellular level takes place. This
knowledge has provided the blueprint for developing better
understanding of the basis of cancer prevention. The transcriptoma
analysis of the breast of pre and post-menopausal women has
established a genomic signature imprinted in the breast that
differs according to the reproductive history of the woman showing
that early first full term pregnancy reprogram the organ. This
reprogramming takes place at the chromatin level by changing the
transcriptional process. The modification of the transcriptional
control is due to the expression of non coding RNA sequences and
posttranscriptional control driven by the splicesome. The
plasticity of the genome of the human breast make possible this
reprogramming that is not only induced by the physiological process
of pregnancy but by the use of hormones that mimic pregnancy
without pregnancy. The author have established the basis of
clinical trials for prevention and the discovery that short 15aa
peptides of the chorionic gonadotropin hormone can be used in human
breast cancer prevention based on preclinical and clinical data.
The book will provide an exhaustive and clear explanation of how
Statistics, Mathematics and Informatics have been used in cancer
research, and seeks to help cancer researchers in achieving their
objectives. To do so, state-of-the-art Biostatistics,
Biomathematics and Bioinformatics methods will be described and
discussed in detail through illustrative and capital examples taken
from cancer research work already published. The book will provide
a guide for cancer researchers in using Statistics, Mathematics and
Informatics, clarifying the contribution of these logical sciences
to the study of cancer, thoroughly explaining their procedures and
methods, and providing criteria to their appropriate use.
|
You may like...
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
|