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Lectins are proteins or glycoproteins of non immune origin which
have a wide distribution in animals, plants, and microorganisms.
Their medicinal role extends from simple antimicrobial action to
anti- tumour properties.In view of the advancement in understanding
the potential medicinal role of the plant lectins, a lectin from
the leaves of Prunella vulgaris was isolated, purified, partially
characterized and its antimicrobial activity evaluated. The lectin
is specific for galactose and N-acetyl-galactosamine The molecular
weight of the lectin as determined by SDS-PAGE was 32500 Da and
that estimated from Sephadex G-100 gel filtration column was 65000
Da indicating that the purified lectin is a homodimer. The purified
lectin also shows a significant antimicrobial activity against the
infectious agents of some common diseases such as Salmonella typhi,
Klebseilla pnuemonea and Escherhia coli.
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