To understand how the cerebral cortex functions requires knowledge of single cells in this region and of their organization into cortical networks. Looking beyond the classical "wiring diagram" description of the organization of cortical cells into circuits, this innovative work focuses on dynamic aspects of cerebral cortical physiology, both at the single-neuron and network levels. Recent years have seen a remarkable expansion of knowledge about the basic cellular physiology and molecular biology of cortical neurons - their membrane properties, their synaptic characteristics, their functional connectivity, their development, and the mechanisms of their response to injury. This authoritative volume includes contributions by many of the renowned neurobiologists and neurologists directly responsible for these advances. It is divided into four main sections, each of which is prefaced with an overview by a leading expert in the field. The sections cover cortical neurons and synapses, the cortical network, the developing cortical neuron, and the vulnerable cortical neuron. This final section focuses on the cortical neuron in relation to the mechanisms of epilepsy. Together, the chapters provide a balanced, up-to-date, multidisciplinary perspective on the normal and pathological function of the cells of the cerebral cortex, identifying the controversies and critical issues facing modern researchers in this exciting field.

Neurobiology of the Epilepsies - From Epilepsy: A Comprehensive Textbook, 3rd Edition, provides a concise, up-to-date review of basic sciences and the latest research advances in epilepsy. Ideal for general neurologists and neurosurgeons, epilepsy/clinical neurophysiology specialists, basic scientists, clinical researchers, and other health care providers with an interest in epilepsy, this new volume by Drs. Istvan Mody, Hal Blumenfeld, Jerome Engel, Jr., Asla Ptkanen, Ivan Soltesz, and Annamaria Vezzani offers comprehensive, authoritative coverage of this critical and complex area of the field. Contains the complete text of Section 3: Neurobiology from Epilepsy: A Comprehensive Textbook, 3rd Edition, by Drs. Jerome Engel, Jr., Solomon L. Moshe, Aristea S. Galanopoulou, and John M. Stern. Offers comprehensive sections on translational aspects of research, neurobiology, recent technical and conceptual advances in research, and other notable contributors to synchrony and seizures Covers major advances in the understanding of the basic mechanisms of epilepsy and its consequences Serves as a source text for translational/basic scientists interested in epilepsy Written and edited by world renowned experts who offer a thorough review of basic sciences and current research in this complex field Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.