This volume explores diverse protocols for peptide conjugation, and provides thoroughly tested and scientifically valid techniques that allow researchers and scientists to prepare, purify, characterize, and use peptide conjugation methods for chemical, biochemical, and biological studies. Some of the topics discussed in this book are gold nanoparticles, proteins, pegylated lipids, and vitamins. Chapters also cover enzymatic ligation using sortase A, construction of a phage-displayed cyclic-peptide library, quantum dot-peptide conjugates, and preparation of lipopeptides by CLipPA chemistry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Conjugation: Methods and Protocols is a valuable resource for experienced researches and undergraduate students alike who are interested in learning more about this exciting and developing field.

This volume explores diverse protocols for peptide conjugation, and provides thoroughly tested and scientifically valid techniques that allow researchers and scientists to prepare, purify, characterize, and use peptide conjugation methods for chemical, biochemical, and biological studies. Some of the topics discussed in this book are gold nanoparticles, proteins, pegylated lipids, and vitamins. Chapters also cover enzymatic ligation using sortase A, construction of a phage-displayed cyclic-peptide library, quantum dot-peptide conjugates, and preparation of lipopeptides by CLipPA chemistry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Conjugation: Methods and Protocols is a valuable resource for experienced researches and undergraduate students alike who are interested in learning more about this exciting and developing field.

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles.

This thesis provides information and analysis of the effects of the 1956 Hungarian Revolution 1956 on the Hungarian military higher education system. Providing a historical overview, the thesis sets up an understanding of the Hungarian military higher education's situation from its establishment until the end of WWII. The thesis explains the process of reestablishment and improvement of the system after WWII. This part provides large amounts of data from 1947 until 1956, setting up the comparison of the system before and after the revolution. It examines the educational institution's role during the days of the revolution, as well as how it affected the lives and careers of many instructors, military officers, and students. This thesis examines the military higher education's situation after the revolution. It provides information and large amounts of data, which serves to explain the changes, as well as, the short and long term effects caused by the revolution. This thesis analyzes many studies and provides interesting data regarding the system, the education institutions, instructors, students, and the Hungarian officers' corps. In summary, the reader can gain an insight into the Hungarian military higher education system during the wildest years of communism in Hungary, as well as the following decades.

At a time when the enlarged European Community asserts the humanist values uniting its members, this series of four volumes, featuring leading scholars from twelve countries, seeks to uncover the deep but hidden unities shaping a common European past. These volumes examine the domains of religion, the city, communication and information, the conception of man and the use of material goods, identifying the links which endured and were strengthened through ceaseless cultural exchanges, even during this time of endless wars and religious disputes. Volume I examines the role of religion as a vehicle for cultural exchange. Volume II surveys the reception of foreigners within the cities of early modern Europe. Volume III explores the place of information and communication in early modern Europe. Volume IV reveals how cultural exchange played a central role in the fashioning of a first European identity.

Knowledge of the basic mechanisms of human disease is essential for any student or professional engaged in drug research and development. Functional gene analysis (genomics), protein analysis (proteomics) and other molecular biological techniques have made it possible to understand these cellular processes, opening up exciting opportunities for novel therapeutic possibilities.
Molecular Pathomechanisms and New Trends in Drug Research presents an in-depth review of the molecular mechanisms involved in a number of common diseases including cancer, AIDS, inflammation, cardiovascular disease and neurodegenerative disorders among others, with particular emphasis on signal transduction and potential therapeutic strategies. It will be a useful reference text for students and researchers in chemistry, biochemistry, medicine and the pharmaceutical sciences.

eBook available with sample pages: 020321997X