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Rubin and Damjanov's latest volume of Pathology Reviews highlights
the latest progress in the interface of biology and disease.
Forefront techniques and experimental models that were once
considered exotic or esoteric, are explored here in the context of
understanding more fully the processes involved in human disease.
Topics include: regulation of liver growth * contractile cells in
lungs * mineral formation in bone * folate metabolism * the "riddle
of the mast cell" * HLA antigens * interleukin 6 * IgA nephropathy
* Goodpasture syndrome * anti-basement membrane
glomerulonephropathy * molecular mechanisms of oncogenesis *
molecular diagnosis of cancer * inhibition of intercellular
communication in carcinogenesis * DNA repair and its pathogenetic
implications * human and rat mammary tumorigenesis. Pathology
Reviews * 1990 is essential reading for everyone concerned with the
mechanisms of disease.
Pathobiology of Human Germ Cell Neoplasia is a state-of-the-art
compendium on a very recent branch of tumor biology. It offers an
awareness and understanding of germ cell tumors: from the earliest
stages to their va- rious differentiations. Original data for this
volume was supplied by experts in the fields of pathology,
developmental biology, genetics, molecular biology and other
related fields. This compilation of knowledge provides information
necessary to persons working in clinical and preclinical areas.
New methods in immunocytochemistry and hybridization techniques
enable the pathologist active in diagnosis to clarify more
effectively problems in the classification and prognosis of tumors.
By adopting these methods into his diagnostic repertoire it will be
possible to create a closer, more productive connection between
morphological diagnosis and clinical work. This volume gives the
reader an up-to-date general survey from international experts of
the method, technique and practical application of these new
procedures.
Human teratocarcinoma has long held a fascination to the
pathologist be- cause of the diversity of the seemingly benign
differentiated tissues asso- ciated with the tumor. An
understanding of this diversity came with the demonstration of the
pluripotent nature of the embryonal carcinoma cell, the stem cell
of the tumor, in experimental animals. Single cell clones of murine
embryonal carcinomas were derived and the resultant cell lines
injected into immunosuppressed hosts, where the embryonal carcinoma
stem cell itself gave rise to the wealth of differentiated tissues
seen in teratocarcinomas. It was also shown that teratocarcinomas
could be pro- duced experimentally by transplantation of staged
early mouse embryo to extrauterine sites; subsequent experiments
suggested that the embryonal carcinoma stem cell was, in fact,
comparable to a normal cell of the em- bryonic ectoderm. Many
elegant experiments have since been built on this early work;
murine embryonal carcinoma cells are providing the ex- perimental
material for a first biochemical evaluation of the earliest dif-
ferentiation events in mammalian embryogenesis. In this volume, we
relate the beginnings of experimental research on human teratoma.
The human embryonal carcinoma cells have been char- acterized and
established in vitro, providing an experimental model to study the
unique biology of these cells. Monoclonal antibodies, estab- lished
from work with these in vitro cultures, provide cell surface probes
that define populations of embryonal cells and their derivatives in
tumor sections.
on the theories of Planck and Einstein. Rather, until The concept
that human disease is a specialized branch of biology is
universally accepted today, but in the mid-20th century, the
accretion of individual historical perspective, is actually of
recent origin. At examples of the biological nature of disease
processes provided the framework for an evolutionary change in one
time, the heliocentric theories of astronomy and the metallurgic
transmutations of alchemy had their thinking. The new psychological
and philosophical milieu provided the basis for an unprecedented
accel counterparts in magical and vitalistic approaches to eration
in the pace of biomedical research. It is clear human disease. Any
relation between disease of humans and that of animals was not only
unacceptable that the biological revolution of the last 35 years
was made possible not only by technological advances and
intellectually, but abhorrent theologically. Humans (and their
diseases) were unique, and biology was the innovative analytical
methods, but also by an intellec domain of those who studied
animals and plants. tual emphasis on the unity of biological
processes. The unification of biology and the study of human High
school students are now aware that there is much disease, though
begun some centuries ago, was con to be learned about the human
condition by studying spicuously stimulated by the work of Darwin,
and bacterial DNA, the chloroplasts of green leaves, or the reached
its full flower in this century. For example, kinetics of enzymes
in vitro."
Human teratocarcinoma has long held a fascination to the
pathologist be- cause of the diversity of the seemingly benign
differentiated tissues asso- ciated with the tumor. An
understanding of this diversity came with the demonstration of the
pluripotent nature of the embryonal carcinoma cell, the stem cell
of the tumor, in experimental animals. Single cell clones of murine
embryonal carcinomas were derived and the resultant cell lines
injected into immunosuppressed hosts, where the embryonal carcinoma
stem cell itself gave rise to the wealth of differentiated tissues
seen in teratocarcinomas. It was also shown that teratocarcinomas
could be pro- duced experimentally by transplantation of staged
early mouse embryo to extrauterine sites; subsequent experiments
suggested that the embryonal carcinoma stem cell was, in fact,
comparable to a normal cell of the em- bryonic ectoderm. Many
elegant experiments have since been built on this early work;
murine embryonal carcinoma cells are providing the ex- perimental
material for a first biochemical evaluation of the earliest dif-
ferentiation events in mammalian embryogenesis. In this volume, we
relate the beginnings of experimental research on human teratoma.
The human embryonal carcinoma cells have been char- acterized and
established in vitro, providing an experimental model to study the
unique biology of these cells. Monoclonal antibodies, estab- lished
from work with these in vitro cultures, provide cell surface probes
that define populations of embryonal cells and their derivatives in
tumor sections.
Pathology for the Health Professions, 6th Edition is the best
resource for clear, concise, and clinically relevant information on
general pathology. Praised for its stunning collection of pathology
images, this engaging, easy-to-understand text covers the most
frequently encountered diseases that you need to know to succeed in
today's healthcare environment. UNIQUE! Each major disease is
presented in a standardized format called DEPPiCT (Disease
description, Etiology, Pathogenesis, Pathology, Clinical features,
and a short discussion on Therapy or prognosis), providing a valid
and useful didactic approach to study and clinical practice. Clear,
non-technical writing style makes complex concepts more engaging
and easier to understand. Learning objectives and review questions
help you identify the most important concepts and test your
understanding of essential principles. Key terms are listed at the
beginning of each chapter and bolded at first mention.
Comprehensive glossary provides easy access to definitions of
terms. NEW! Streamlined content is more accessible and easier to
read. UPDATED! Did You Know? boxes showcase interesting clinical
and public health data. UPDATED! More than 500 high-quality,
full-color images visually reinforce your understanding of disease
conditions and general pathology principles.
This is the second edition of a practice-oriented, well-illustrated
manual on the microscopic grading of tumors. After an introduction
on the history and basic tenets of tumor grading, subsequent
chapters focus on specific organ systems. In each case, the most
widely used system for grading common tumors is presented and
discussed. Throughout, careful attention is paid to the principles
of microscopic tumor grading, ancillary methods to improve grading,
and the latest techniques used in evaluating tumors and formulating
prognosis. Since the first edition, all chapters have been updated
to reflect revisions in the clinical practice of pathology and to
explain the role of novel immunohistochemistry and molecular
biology techniques. In addition, a new chapter is devoted to the
latest trends in cancer grading, and further illustrations have
been included. Cancer Grading Manual is a superb resource for both
diagnostic surgical pathologists and pathology residents.
This book is a review of gynaecologic and breast pathology for
clinicians and trainees. Divided into seven sections, topics are
presented in question and answer format, covering both common and
less common pathologies that may be encountered in female genital
and reproductive organs and the breast. The final section of the
book covers immunohistochemistry and cytogenetics of tumours in
these organs. Questions and answers are both textual and visual,
based on microphotographs illustrating key pathologic entities.
Authored by recognised pathologists led by Prof Ivan Damjanov from
University of Kansas School of Medicine, the text is enhanced by
colour microphotographs and figures. Key points Review of
gynaecologic and breast pathology for clinicians and trainees
Presented in question and answer format Includes section on
immunohistochemistry and cytogenetics of tumours Recognised author
team led by Prof Ivan Damjanov
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