This book constitutes the refereed proceedings of the 42nd International Conference on Computer Safety, Reliability and Security, SAFECOMP 2023, which took place in Toulouse, France, in September 2023.The 20 full papers included in this volume were carefully reviewed and selected from 100 submissions. They were organized in topical sections as follows: Safety assurance; software testing and reliability; neural networks robustness and monitoring; model-based security and threat analysis; safety of autonomous driving; security engineering; AI safety; and neural networks and testing.

This book constitutes the proceedings of the Workshops held in conjunction with SAFECOMP 2023, held in Toulouse, France, during September 19, 2023. The 35 full papers included in this volume were carefully reviewed and selected from 49 submissions.  -        - 8th International Workshop on Assurance Cases for Software-intensive Systems (ASSURE 2023) -        - 18th International Workshop on Dependable Smart Embedded and Cyber-Physical Systems and Systems-of-Systems (DECSoS 2023) -        - 10th International Workshop on Next Generation of System Assurance Approaches for Critical Systems (SASSUR 2023) -        - Second International Workshop on Security and Safety Interactions (SENSEI 2023) -        - First International Workshop on Safety/ Reliability/ Trustworthiness of Intelligent Transportation Systems (SRToITS 2023) -        - 6th International Workshop on Artificial Intelligence Safety Engineering (WAISE 2023)